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    A DEVICE AND A METHOD FOR MANAGING A SAMPLE TO BE ANALYZED AND A SOLID SAMPLE CARRIER AND LIQUID SAMPLE CARRIER
    1.
    发明公开
    A DEVICE AND A METHOD FOR MANAGING A SAMPLE TO BE ANALYZED AND A SOLID SAMPLE CARRIER AND LIQUID SAMPLE CARRIER 审中-公开

    公开(公告)号：EP3859301A1

    公开(公告)日：2021-08-04

    申请号：EP20207724.4

    申请日：2015-02-02

    申请人： Wallac OY

    发明人： KORPIMÄKI, Teemu

    IPC分类号： G01N1/28 ,  G01N35/00 ,  G01N35/10

    摘要： A device for managing a sample to be analyzed comprises magnetizing equipment (302) for producing magnetic field capable of interacting, when the sample is moving to or located in a sample well, with magnetically amplifying material attached to the sample, where the magnetically amplifying material has relative magnetic permeability constant greater than one. With the aid of the magnetizing element the movement of the sample to the sample well and/or the position of the sample in the sample well can be monitored and/or controlled. The device can be, for example but not necessarily, an instrument for dispensing samples to sample wells or an optical measurement instrument.

    SYSTEM AND METHOD FOR DETERMINING RISK OF DIABETES BASED ON BIOCHEMICAL MARKER ANALYSIS
    4.
    发明公开
    SYSTEM AND METHOD FOR DETERMINING RISK OF DIABETES BASED ON BIOCHEMICAL MARKER ANALYSIS 有权
    系统在VERFAHREN ZUR BESTIMMUNG DES DIABETESRISIKOS AUF基础DER分析生物化学品商标

    公开(公告)号：EP2972385A2

    公开(公告)日：2016-01-20

    申请号：EP14715412.4

    申请日：2014-02-26

    申请人： WALLAC OY

    发明人： HURSKAINEN, Pertti ,  KORPIMÄKI, Teemu ,  KOURU, Heikki ,  SAIRANEN, Mikko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2333/8132 ,  G01N2800/042 ,  G01N2800/368 ,  G01N2800/54

    摘要： A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

    摘要翻译： 用于预测怀孕个体的妊娠糖尿病（GDM）的风险的方法包括测量从怀孕个体获得的血液样品中的一种或多种生物化学标记物，以确定一种或多种生物标志物水平，其中所述一种或多种测量的生物化学标记物包括在 PAI-2和sTNFR1中的至少一个，针对所述一个或多个测量的生物化学标记中的每一个标识所测量的生物标志物水平与相应的预定控制水平之间的差异，并且响应于所述鉴定，确定对应于相对 怀孕个体患有或发展GDM的风险。

    METHOD FOR DETERMINING THE RISK OF PRETERM BIRTH
    6.
    发明公开
    METHOD FOR DETERMINING THE RISK OF PRETERM BIRTH 审中-公开
    确定预产生风险的方法

    公开(公告)号：EP3194979A1

    公开(公告)日：2017-07-26

    申请号：EP15774940.9

    申请日：2015-09-11

    申请人： Wallac OY

    发明人： HURSKAINEN, Pertti ,  KOURU, Heikki ,  SAIRANEN, Mikko ,  AHOLA, Tarja ,  KORPIMÄKI, Teemu

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2800/368

    摘要： The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCG-beta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

    摘要翻译： 本发明涉及用于确定怀孕个体中早产风险（PTB）的方法。 该方法包括测量从怀孕个体获得的生物样品中生物标志物AFP和游离hCGβ的水平以及选自FSTL3，sTNR1，PlGF2，激活素A，Ue3和sP-选择素和任选的宫颈长度的至少一种生物标志物; 或生物标志物AFP和游离hCGβ和宫颈长度的水平，并确定怀孕个体发展PTB的相对风险。 本发明还涉及预测PTB风险的试剂盒，装置和系统。

    METHOD FOR DETERMINING THE RISK OF PREECLAMPSIA USING PIGF-2 AND PIGF-3 MARKERS
    7.
    发明公开
    METHOD FOR DETERMINING THE RISK OF PREECLAMPSIA USING PIGF-2 AND PIGF-3 MARKERS 有权
    使用PIGF-2和PIGF-3标记物确定PREECLAMPSIA风险的方法

    公开(公告)号：EP2368119A1

    公开(公告)日：2011-09-28

    申请号：EP09760061.3

    申请日：2009-11-20

    申请人： PerkinElmer Health Sciences, Inc. ,  NTD Laboratories, Inc. ,  WALLAC OY

    发明人： AHOLA, Tarja ,  FRANG, Heini ,  KORPIMÄKI, Teemu ,  HURSKAINEN, Pertti ,  BOBROW, Mark N. ,  CARMICHAEL, Jonathan B.

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2800/368 ,  G06F19/28

    摘要： The present invention relates to a method for determining the risk of a pregnant woman developing pre-eclampsia. The method comprises i) determining the level of one or more biochemical markers in a sample obtained from a pregnant woman, and ii) comparing the level of the at least one biochemical marker in the sample with the level of the same biochemical marker in a control sample. A difference in the level of the biochemical marker in the sample relative to the control sample is indicative of an increased risk of developing pre-eclampsia. The isoform biochemical markers are preferably PlGF-2 and PlGF-3. The present invention relates also to a method for determining whether a pregnant woman has pre-eclampsia and as well as a kit for assessing the risk or presence of pre-eclampsia. In addition, the invention relates also to a computer program used in these determinations.

    摘要翻译： 本发明涉及用于确定孕妇发展先兆子痫的风险的方法。 该方法包括：i）确定从孕妇获得的样品中的一种或多种生化标志物的水平，以及ii）将样品中的至少一种生化标志物的水平与对照中的相同生化标志物的水平进行比较 样品。 样品中生物化学标志物水平相对于对照样品的差异表明发生先兆子痫的风险增加。 同种型生化标志物优选为PlGF-2和PlGF-3。 本发明还涉及用于确定孕妇是否患有先兆子痫的方法以及用于评估先兆子痫的风险或存在的试剂盒。 另外，本发明还涉及用于这些确定的计算机程序。

    SYSTEM AND METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA BASED ON BIOCHEMICAL MARKER ANALYSIS
    8.
    发明公开
    SYSTEM AND METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA BASED ON BIOCHEMICAL MARKER ANALYSIS 审中-公开
    系统VERFAHREN ZUR BESTIMMUNG EINESFRÜHGEBURTSRISIKOSAUF基础分析生物化学品商标

    公开(公告)号：EP2972383A1

    公开(公告)日：2016-01-20

    申请号：EP14713260.9

    申请日：2014-02-26

    申请人： WALLAC OY

    发明人： HURSKAINEN, Pertti ,  KORPIMÄKI, Teemu ,  KOURU, Heikki ,  SAIRANEN, Mikko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2800/368 ,  G01N2800/50 ,  G16B40/00

    摘要： A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.

    摘要翻译： 用于预测怀孕个体中先兆子痫风险的方法包括在从怀孕个体获得的血液样品中测量一种或多种生物化学标志物，包括RBP4生物化学标志物，以确定包括RBP4生物标志物水平的一种或多种生物标志物水平，鉴定 所述一个或多个测量的生物化学标记中的每一个，所测量的生物标志物水平与相应的预定对照水平之间的差异，并且响应于所述鉴定，确定对应于具有或发展先兆子痫的孕妇的相对风险的预测。