公开(公告)号：EP1746999B1

公开(公告)日：2011-11-16

申请号：EP05732761.1

申请日：2005-04-25

申请人： Warner-Lambert Company LLC

发明人： FAKHOURY, Stephen, Alan ,  LEE, Helen, Tsenwhei ,  REED, Jessica, Elizabeth ,  SCHLOSSER, Kevin, Matthew ,  SEXTON, Karen, Elaine ,  TECLE, Haile ,  WINTERS, Roy, Thomas

IPC分类号： A61K31/505 ,  C07D239/94 ,  A61P43/00 ,  A61P35/00

CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D403/12

摘要： This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n—-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

公开(公告)号：EP1915338A2

公开(公告)日：2008-04-30

申请号：EP06795256.4

申请日：2006-07-27

申请人： Warner-Lambert Company LLC

发明人： BOYS, Mark, Laurence ,  BRUENDL, Michelle, Marie ,  DOWNS, Victoria, Leigh ,  FAKHOURY, Stephen, Alan ,  HARTER, William, Glen ,  HU, Lain-Yen ,  JENNINGS, Sandra, Marie ,  LEFKER, Bruce, Allen ,  MITCHELL, Lorna, Helen ,  RAHEJA, Raj, Kumar ,  SMITH, Yvonne, Dorothy

IPC分类号： C07C255/54 ,  C07D213/30 ,  A61K31/277

CPC分类号： C07C255/54 ,  C07C2601/02 ,  C07D213/30 ,  C07D213/64 ,  C07D213/65 ,  C07D309/12 ,  C07D319/20

摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

摘要翻译： 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。