公开(公告)号：EP1746999B1

公开(公告)日：2011-11-16

申请号：EP05732761.1

申请日：2005-04-25

申请人： Warner-Lambert Company LLC

发明人： FAKHOURY, Stephen, Alan ,  LEE, Helen, Tsenwhei ,  REED, Jessica, Elizabeth ,  SCHLOSSER, Kevin, Matthew ,  SEXTON, Karen, Elaine ,  TECLE, Haile ,  WINTERS, Roy, Thomas

IPC分类号： A61K31/505 ,  C07D239/94 ,  A61P43/00 ,  A61P35/00

CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D403/12

摘要： This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n—-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N (C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

公开(公告)号：EP1003745B1

公开(公告)日：2004-12-29

申请号：EP98939941.5

申请日：1998-08-13

申请人： WARNER-LAMBERT COMPANY LLC

发明人： BARVIAN, Mark, Robert ,  DENNY, William, Alexander ,  DOBRUSIN, Ellen, Myra ,  HAMBY, James, Marino ,  SHOWALTER, Howard, Daniel, Hollis ,  THOMPSON, Andrew, Mark ,  WINTERS, Roy, Thomas ,  WU, Zhipei

IPC分类号： C07D471/04 ,  A61K31/44

CPC分类号： C07D471/04

摘要： Naphthyridinones of Formula (I) are inhibitors of PTKs and cell cycle kinases, and are useful in treating cellular proliferation. The compounds are especially useful in treating cancer, atherosclerosis, restenosis, and psoriasis.