-
1.发明授权BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权支链氨基酸依赖性氨基转移酶的抑制剂，它们在神经退行性疾病的治疗
公开(公告)号：EP1320523B1
公开(公告)日：2005-06-22
申请号：EP01964182.8
申请日：2001-08-17
发明人： BORA, Keenan, Martin , HU, Lain-Yen , KESTEN, Suzanne, Ross , LEI, Huanyshu , MORELAND, David, Winslow , RAFFERTY, Michael, Francis , RYDER, Todd, Robert , SCHOLTEN, Jeffrey, David , WUSTROW, David, Juergen
IPC分类号： C07D209/18
CPC分类号： C07D307/79 , C07C311/49 , C07D209/08 , C07D209/30 , C07D209/88 , C07D215/48 , C07D215/50 , C07D307/84 , C07D307/91 , C07D307/92
摘要： The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
-
2.发明公开BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权支链氨基酸依赖性氨基转移酶的抑制剂，它们在神经退行性疾病的治疗
公开(公告)号：EP1320523A2
公开(公告)日：2003-06-25
申请号：EP01964182.8
申请日：2001-08-17
发明人： BORA, Keenan, Martin , HU, Lain-Yen , KESTEN, Suzanne, Ross , LEI, Huanyshu , MORELAND, David, Winslow , RAFFERTY, Michael, Francis , RYDER, Todd, Robert , SCHOLTEN, Jeffrey, David , WUSTROW, David, Juergen
IPC分类号： C07D209/18
CPC分类号： C07D307/79 , C07C311/49 , C07D209/08 , C07D209/30 , C07D209/88 , C07D215/48 , C07D215/50 , C07D307/84 , C07D307/91 , C07D307/92
摘要： The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
-
搜索结果
2 条记录 (耗时 0.012 秒)
