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1.发明公开Octanoic acid derivative to treat fibromyalgia and other pains 审中-公开OctansäureDerivat zur Behandlung von Fibromyalgia und anderen Schmerzen
公开(公告)号：EP2172197A1
公开(公告)日：2010-04-07
申请号：EP09175270.9
申请日：2003-12-03
IPC分类号： A61K31/195 , A61P43/00
CPC分类号： A61K45/06 , A61K31/195
摘要： The invention relates to the use of (3S,5R)-3-aminomethyl-5-methyloctanoic acid, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment of a mammal for a disorder selected from fibromyalgia, abdominal or gynaecological pain, and pain caused by increased bladder contractions.
摘要翻译： 本发明涉及（3S，5R）-3-氨基甲基-5-甲基辛酸或其药学上可接受的盐在制备用于治疗哺乳动物的药物中的用途，所述疾病选自纤维肌痛，腹部或 妇科疼痛和膀胱收缩增加引起的疼痛。
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公开(公告)号：EP1492761B1
公开(公告)日：2009-07-22
申请号：EP03706831.9
申请日：2003-03-17
IPC分类号： C07C229/08 , C07C229/28 , A61K31/195 , A61P25/00 , A61P1/00
CPC分类号： C07C229/08 , A61K31/195 , A61K31/198 , C07C229/28 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , Y02A50/415
摘要： The invention relates to compounds of the formula II, III and IV, compositions comprising them and their use in the treatment of, inter alia, pain.
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公开(公告)号：EP1840117A1
公开(公告)日：2007-10-03
申请号：EP07112764.1
申请日：2000-05-31
发明人： Belliotti, Thomas Richard , Bryans, Justin Stephen , Ekhato, Ihoezo Victor , Osuma, Augustine Tobi , Schelkun, Robert Michael , Thorpe, Andrew John , Wise, Lawrence David , Wustrow, David Juergen , Yuen, Po-Wai , Schwarz, Jacop Bradley
IPC分类号： C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , A61K31/197 , A61P25/00 , A61P1/00
CPC分类号： C07C229/08 , C07B2200/07 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I
The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.摘要翻译： 本发明是一系列新颖的式I的单取代和二取代的3-丙基γ-氨基丁酸。该化合物可用作治疗癫痫，微弱发作，运动功能减退，颅内疾病，神经变性障碍，抑郁，焦虑，恐慌的治疗剂 ，疼痛，神经病理学障碍，关节炎，睡眠障碍，IBS和胃损伤。 制备化合物和有用的中间体的方法也是本发明的一部分。
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4.发明公开AMINO ACIDS WITH AFFINITY FOR THE ALPHA2DELTA-PROTEIN 审中-公开AMINOSÄURENMITAFFINITÄTZUM ALPHA-2-DELTA-PROTEIN
公开(公告)号：EP1667957A2
公开(公告)日：2006-06-14
申请号：EP04769374.2
申请日：2004-09-13
发明人： Deur, Christopher James , Kolz, Christine Nylund , Osuma, Augustine Tobi , Plummer, Mark Stephen , Schwarz, Jacob Bradley , Thorpe, Andrew John , Wustrow, David Juergen
IPC分类号： C07C229/08 , C07C229/28 , C07C229/34 , A61K31/197 , A61P23/00
CPC分类号： C07C229/08 , C07B2200/07 , C07C227/32 , C07C229/28 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D263/26 , Y02P20/582
摘要： Certain ß-amino acids that bind to the alpha-2-delta (a2S) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
摘要翻译： 公开了结合钙通道的α-2-δ（α2delta）亚基的某些β-氨基酸。 这些化合物及其药学上可接受的盐可用于治疗各种精神病，疼痛和其它疾病。 还公开了制备β-氨基酸的方法。
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5.发明公开AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA-PROTEIN 有权AMINOSÄURENMITAFFINITÄTZU ALPHA-2-DELTA-PROTEIN
公开(公告)号：EP1492761A2
公开(公告)日：2005-01-05
申请号：EP03706831.9
申请日：2003-03-17
IPC分类号： C07C229/08 , C07C229/28 , A61K31/195 , A61P25/00 , A61P1/00
CPC分类号： C07C229/08 , A61K31/195 , A61K31/198 , C07C229/28 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , Y02A50/415
摘要： The invention relates to compounds of the formula II, III and IV, compositions comprising them and their use in the treatment of, inter alia, pain.
摘要翻译： 本发明涉及式II，III和IV的化合物，包含它们的组合物及其在治疗疼痛方面的用途。
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