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1.发明授权(S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS 有权（S）-BENZOCHINOLIZINCARBONSÄUREN和它们作为抗菌剂
公开(公告)号：EP1175217B8
公开(公告)日：2009-03-18
申请号：EP00939047.7
申请日：2000-05-08
申请人： Wockhardt Limited
发明人： PATEL, M.V. Wockhardt Research Center, , GUPTE, S.V. Wockhardt Research Center, , CHUGH, Y. Wockhardt Research Center , SAOJI, D.G. Wockhardt Research Center, , AGARWAL, S.K. Wockhardt Research Center , DE SOUZA, N.J. Wockhardt Research Center, , KHORAKIWALA, H.F., Wockhardt Research Center
IPC分类号： A61K31/4745 , A61P31/04 , A61P31/06 , C07D455/04
CPC分类号： C07C279/14 , A61K31/4745 , C07B2200/07 , C07D455/04 , Y02A50/473
摘要： The present invention relates to S-(-)-optically pure benzoquinolizine carboxylic acid of formula I, and their pharmaceutically acceptable salts, substantially free of their R-(+)-isomers, to processes for their preparation and to pharmaceutical compositions comprising an active compound of the invention. The compounds have excellent antibacterial activity. The compounds and compositions can be used for the treatment of local and systemic bacterial infections, diseases and disorders caused by antibiotic-sensitive and antibiotic-resistant microbial strains, without the concomitant liability of adverse effects associated with the racemic mixture of the active compound of the invention.
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2.发明授权(S)-BENZOQUINOLIZINE CARBOXYLIC ACIDS AND THEIR USE AS ANTIBACTERIAL AGENTS 有权（S）-BENZOCHINOLIZINCARBONSÄUREN和它们作为抗菌剂
公开(公告)号：EP1175217B1
公开(公告)日：2008-12-03
申请号：EP00939047.7
申请日：2000-05-08
申请人： Wockhardt Limited
发明人： PATEL, M.V. Wockhardt Research Center, , GUPTE, S.V. Wockhardt Research Center, , CHUGH, Y. Wockhardt Research Center , SAOGI, D.G. Wockhardt Research Center, , AGARWAL, S.K. Wockhardt Research Center , DE SOUZA, N.J. Wockhardt Research Center, , KHORAKIWALA, H.F., Wockhardt Research Center
IPC分类号： A61K31/4745 , A61P31/04 , A61P31/06 , C07D455/04
CPC分类号： C07C279/14 , A61K31/4745 , C07B2200/07 , C07D455/04 , Y02A50/473
摘要： The present invention relates to S-(-)-optically pure benzoquinolizine carboxylic acid of formula I, and their pharmaceutically acceptable salts, substantially free of their R-(+)-isomers, to processes for their preparation and to pharmaceutical compositions comprising an active compound of the invention. The compounds have excellent antibacterial activity. The compounds and compositions can be used for the treatment of local and systemic bacterial infections, diseases and disorders caused by antibiotic-sensitive and antibiotic-resistant microbial strains, without the concomitant liability of adverse effects associated with the racemic mixture of the active compound of the invention.
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