SOLID ORAL PHARMACEUTICAL COMPOSITIONS COMPRISING FIXED DOSE COMBINATION OF METFORMIN AND SITAGLIPTIN OR SALTS THEREOF
    8.
    发明公开
    SOLID ORAL PHARMACEUTICAL COMPOSITIONS COMPRISING FIXED DOSE COMBINATION OF METFORMIN AND SITAGLIPTIN OR SALTS THEREOF 审中-公开
    固体口服药物组合物FIXDOSIERUNGSKOMBINATION二甲双胍和西他列汀或其盐

    公开(公告)号:EP3033075A1

    公开(公告)日:2016-06-22

    申请号:EP14721970.3

    申请日:2014-03-21

    申请人: Wockhardt Limited

    摘要: The present invention provides solid oral pharmaceutical compositions comprising combination of metformin and sitagliptin or salts thereof. In particular, the present invention relates to a multilayered coated pharmaceutical composition comprising at least two compartments of metformin or salts thereof exhibiting immediate and extended release and at least one compartment of sitagliptin and metformin or salts thereof exhibiting immediate release. The invention also includes process of preparing such compositions and method of use of such compositions for treating type II diabetes.

    摘要翻译: 本发明提供了固体口服药物组合物包含二甲双胍和西他列汀或其盐的组合物。 特别地,本发明涉及多层涂覆的药物组合物包含二甲双胍的至少两个隔室或其盐参展立即和延长释放和西他列汀的至少一个隔室和二甲双胍或其盐参展立即释放。 因此,本发明包括制备寻求组合物和使用组合物的搜索的方法,用于治疗II型糖尿病的方法。

    PHARMACEUTICAL MICROPARTICULATE COMPOSITIONS OF POLYPEPTIDES
    10.
    发明公开
    PHARMACEUTICAL MICROPARTICULATE COMPOSITIONS OF POLYPEPTIDES 审中-公开
    MIKROPARTIKULÄREPHARMAZEUTISCHE ZUSAMMENSETZUNGEN AUS POLYPEPTIDEN

    公开(公告)号:EP2934562A1

    公开(公告)日:2015-10-28

    申请号:EP13729087.0

    申请日:2013-05-02

    申请人: Wockhardt Limited

    摘要: The present invention refers to pharmaceutical microparticulate compositions of biologically active polypeptides and methods of forming and using such compositions. More particularly, microparticle compositions for sustained release of biologically active polypeptides are provided. Compositions of biologically active polypeptides with desired release profile can be prepared without using any sugar. The microparticle compositions of this invention comprise a biocompatible polymer, a biologically active polypeptide, and optionally, pharmaceutical excipients other than sugar.

    摘要翻译: 本发明涉及生物活性多肽的药物微粒组合物以及形成和使用这些组合物的方法。 更具体地,提供用于持续释放生物活性多肽的微粒组合物。 具有所需释放曲线的生物活性多肽的组合物可以在不使用任何糖的情况下制备。 本发明的微粒组合物包含生物相容的聚合物,生物活性多肽和任选的糖以外的药物赋形剂。