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1.发明公开PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY 有权恩他卡朋，左旋多巴和卡比多巴与提高的生物利用率的药物组合物
公开(公告)号：EP2252284A1
公开(公告)日：2010-11-24
申请号：EP09709056.7
申请日：2009-02-06
IPC分类号： A61K31/275 , A61K9/14 , A61K47/26 , A61K9/16 , A61K9/26 , A61K31/195 , A61K31/198
CPC分类号： A61K9/14 , A61K9/145 , A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K31/195 , A61K31/198 , A61K31/275 , A61K31/277
摘要： The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions.
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2.发明授权PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY 有权恩他卡朋，左旋多巴和卡比多巴与提高的生物利用率的药物组合物
公开(公告)号：EP2252284B1
公开(公告)日：2011-05-25
申请号：EP09709056.7
申请日：2009-02-06
IPC分类号： A61K31/275 , A61K9/14 , A61K47/26 , A61K9/16 , A61K9/26 , A61K31/195 , A61K31/198
CPC分类号： A61K9/14 , A61K9/145 , A61K9/1635 , A61K9/1652 , A61K9/2054 , A61K9/2077 , A61K31/195 , A61K31/198 , A61K31/275 , A61K31/277
摘要： The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions.
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