公开(公告)号：EP3207125A1

公开(公告)日：2017-08-23

申请号：EP15798556.5

申请日：2015-10-13

申请人： Wroclawskie Centrum Badan EIT + SP Z O.O.

发明人： MARYCZ, Krzysztof ,  SMIESZEK, Agnieszka

IPC分类号： C12N5/074 ,  A61K31/155 ,  C12N5/0789

CPC分类号： C12N5/0607 ,  A61K31/155 ,  C12N5/0647 ,  C12N2501/105 ,  C12N2501/999

摘要： The object of the present invention is a preparation for pluripotent very small embryonic/epiblast-like stem cells (VSELs) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood, characterised in that it contains metformin, and the usage of metformin for pluripotent very small embryonic/epiblast-like stem cells (VSEL) and hematopoietic stem/progenitor cells (HSPC) CD34+ mobilisation from bone marrow to peripheral blood and for use in treatment or prevention of conditions associated with reduced regenerative potential or premature senescence of cells.

摘要翻译： 本发明的目的是从骨髓到外周血的多能非常小的胚胎/上胚层样干细胞（VSEL）和造血干/祖细胞（HSPC）CD34 +动员的制备，其特征在于它含有二甲双胍， 使用二甲双胍从骨髓到外周血的多能非常小的胚胎/上胚层样干细胞（VSEL）和造血干/祖细胞（HSPC）CD34 +动员，并用于治疗或预防与降低的再生潜能或早产相关的病症 细胞衰老。