-
公开(公告)号：EP4289843A1
公开(公告)日：2023-12-13
申请号：EP22749253.5
申请日：2022-02-08
发明人： ZHANG, Xuejun , CHANG, Shaohua , LI, Xueqiang , YE, Dabing , WANG, Hongqiang , SUN, Hongna , YANG, Jun , LI, Li'e
IPC分类号： C07D471/04 , C07D453/02 , C07D519/00 , A61K31/519 , A61P35/00 , A61P35/02
摘要： A pyridopyrimidinone derivative as represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof or a prodrug thereof. The pyridopyrimidinone derivative has a good SOS1 inhibitory effect.
-
公开(公告)号：EP4434986A1
公开(公告)日：2024-09-25
申请号：EP22894954.1
申请日：2022-11-18
发明人： ZHANG, Xuejun , LI, Xueqiang , WANG, Hongqiang , YE, Dabing , WANG, Meng , AN, Dan , GAO, Zhenxing , ZHAO, Xin , LI, Li'e , YANG, Jun
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4375 , A61K31/517 , A61P1/04 , A61P9/00 , A61P1/16 , A61P29/00
CPC分类号： A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/4545 , A61K31/4725 , A61K31/517 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/04 , A61P27/02 , A61P27/04 , A61P27/06 , A61P27/16 , A61P29/00 , C07D471/04 , C07D487/04 , C07D519/00
摘要： Provided are a 15-PGDH inhibitor and the use thereof. The 15-PGDH inhibitor is a heterocyclic compound as represented by formula I, a solvate thereof, a pharmaceutically acceptable salt thereof, a solvate of a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compound has a good inhibitory effect on 15-PGDH.
-
公开(公告)号：EP4242204A1
公开(公告)日：2023-09-13
申请号：EP21888667.9
申请日：2021-11-05
发明人： ZHANG, Xuejun , CHANG, Shaohua , YE, Dabing , LEI, Sijun , WANG, Yonggang , LIU, Yong , SUN, Hongna , YANG, Jun , LI, Lie
IPC分类号： C07D403/04 , A61P35/00 , A61K31/513
摘要： The present disclosure provides a novel compound for effectively inhibiting the activity of CD73, a preparation method thereof, and use thereof in the preparation of drugs, and the novel compound is a compound represented by formula I, or a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt, or prodrug thereof.
-
公开(公告)号：EP3919498A1
公开(公告)日：2021-12-08
申请号：EP20748342.1
申请日：2020-01-22
发明人： ZHANG, Xuejun , YE, Dabing , LI, Lie , SHEN, Jie , DING, Xiaohua , SUN, Hongna , LIU, Zhe , ZANG, Yang , WEI, Yonggang
IPC分类号： C07D487/04
摘要： Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), R 1 and R 2 are independently selected from -H or -CH 3 , provided that: R 1 and R 2 are not -H at the same time or are not -CH 3 at the same time.
-
-
-
搜索结果
4 条记录 (耗时 0.016 秒)
