公开(公告)号：EP1645864B1

公开(公告)日：2013-07-10

申请号：EP05021705.8

申请日：2005-10-05

申请人： WYATT TECHNOLOGY CORPORATION

发明人： Larkin, Michael I. ,  Trainoff, Steven P.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

公开(公告)号：EP1560016A1

公开(公告)日：2005-08-03

申请号：EP04024332.1

申请日：2004-10-13

申请人： Wyatt Technology Corporation

发明人： Larkin, Michael I.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

摘要： A sensitivity-enhanced flow cell to be used in the determination of the differential refractive index increment of a sample fluid relative to a reference fluid is disclosed. The invention permits the use of smaller sample amounts without sacrificing overall sensitivity. Equally important, said improved How cell produces measurements of increased precision without requirement for increased sample amount. This is achieved by means of two chambers within said cell whose volumes are different. The sample fluid chamber is the smaller of the two with the reference fluid chamber constructed so that the incident illumination beam, upon passage through said sample chamber and displacement by the partition element located therebetween said sample and reference chambers, passes through said reference chamber without grazing any of the confining walls or striking corners of said sensitivity-enhanced flow cell. As the amount of deflection of said transmitted beam depends upon the refractive indices of the fluids relative to the transparent matter of which the containing cell is comprised, as well as the RI difference between said fluids themselves, the reference chamber is designed to transmit said incident light beam without grazing degradation thereof for all practical ranges of expected fluid and cell refractive indices.

摘要翻译： 公开了用于确定样本流体相对于参考流体的差示折射率增量的灵敏度增强流动单元。 本发明允许使用较小的样品量而不牺牲总体灵敏度。 同样重要的是，改进的细胞如何提高测量精度而不需要增加样品量。 这是通过在体积不同的所述单元内的两个室来实现的。 样品流体室是两个中较小的一个，其中参考流体室构造成使得入射照射束在通过所述样品室并且通过位于其间的分隔元件移位时使所述样品室和参考室在没有放牧的情况下穿过所述参考室 所述灵敏度增强的流动池的任何限制壁或撞击角。 由于所述透射光束的偏转量取决于流体相对于包含所述容纳单元的透明物质的折射率以及所述流体本身之间的RI差异，所述参考腔室被设计成将所述事件 光束不会在所有预期的流体和单元折射率的实际范围内变差。

公开(公告)号：EP1538435A2

公开(公告)日：2005-06-08

申请号：EP04013578.2

申请日：2004-06-09

申请人： Wyatt Technology Corporation

发明人： Larkin, Michael I.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

摘要： A cell for a walk-off refractometer is disclosed that permits measurement of the differential refractive index, DRI, between a sample fluid and a reference fluid. In addition, the new cell design permits the measurement of the refractive index, RI, of a fluid relative to the refractive index of the material comprising or surrounding the flow cell. Thus a single instrument may be used to measure separately the RI of a sample fluid and the DRI between a sample fluid and a reference fluid. The new flow cell contains two chambers, typical of a DRI instrument, but an asymmetric internal angle in either the sample or the reference chamber. By the provision of this structure, it is an objective of this invention to be able to measure the refractive index of a fluid relative to the refractive index of the material comprising the flow cell or relative to the medium surrounding the flow cell, either of which may be considered a measurement of the RI of the fluid. With the addition of mirror means, it is the further objective of this invention to improve its sensitivity. A further objective of the invention is to measure the asymmetric internal angle of the flow cell using well-characterized reference fluids.

摘要翻译： 公开了一种用于离散折射计的电池，其允许测量样品流体和参考流体之间的差示折射率DRI。 此外，新的电池设计允许测量流体相对于包含或围绕流动池的材料的折射率的折射率RI。 因此，可以使用单个仪器来单独测量样品流体的RI和样品流体和参考流体之间的DRI。 新的流通池包含两个典型的DRI仪器室，但在样品或参考室中都有不对称内角。 通过提供这种结构，本发明的目的是能够测量流体相对于包含流动池的材料的折射率或相对于围绕流动池的介质的折射率，其中任何一种 可以被认为是流体的RI的测量。 通过添加镜面装置，本发明的另一个目的是提高其灵敏度。 本发明的另一个目的是使用良好表征的参考流体来测量流动池的不对称内角。

公开(公告)号：EP1538435B1

公开(公告)日：2009-08-19

申请号：EP04013578.2

申请日：2004-06-09

申请人： WYATT TECHNOLOGY CORPORATION

发明人： Larkin, Michael I.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

公开(公告)号：EP1645864A2

公开(公告)日：2006-04-12

申请号：EP05021705.8

申请日：2005-10-05

申请人： WYATT TECHNOLOGY CORPORATION

发明人： Larkin, Michael I. ,  Trainoff, Steven P.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

摘要： An improved differential refractometer incorporating a photodetector array is disclosed. Using a multi-element photo array provides the basis for measurement of differential refractive index values with a heretofore unattainable combination of sensitivity of measurement and concurrent range of measurement. Within the large dynamic range attainable, the detector structure provides equal sensitivity irrespective of deflection within the range. The transmitted light beam is tailored to provide a spatial variation of the light intensity at the array improving thereby the precision of measurement of its displacement. This in turn results in improved precision in the reported differential refractive index and in the calculation of the differential refractive index increment dn / dc . Integrating the detector array into the flow cell structure of the parent case results in a detector of exceptional sensitivity and range for sample quantities far smaller than required by conventional differential refractometers.

摘要翻译： 公开了一种结合光电检测器阵列的改进的差示折射计。 使用多元素照片阵列提供了测量差异折射率值的基础，与测量灵敏度和同时测量范围无法实现的组合。 在可获得的大动态范围内，检测器结构提供相等的灵敏度，而与范围内的偏转无关。 调整透射光束以提供阵列处的光强度的空间变化，从而提高其位移的测量精度。 这又导致报告的折射率的差异性和差分折射率增量dn / dc的计算精度的提高。 将检测器阵列集成到母机箱的流通池结构中，可以得到远远小于常规差示折光仪所需的样品量的特殊灵敏度和范围的检测器。

公开(公告)号：EP1645864A3

公开(公告)日：2006-05-24

申请号：EP05021705.8

申请日：2005-10-05

申请人： WYATT TECHNOLOGY CORPORATION

发明人： Larkin, Michael I. ,  Trainoff, Steven P.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

摘要： An improved differential refractometer incorporating a photodetector array is disclosed. Using a multi-element photo array provides the basis for measurement of differential refractive index values with a heretofore unattainable combination of sensitivity of measurement and concurrent range of measurement. Within the large dynamic range attainable, the detector structure provides equal sensitivity irrespective of deflection within the range. The transmitted light beam is tailored to provide a spatial variation of the light intensity at the array improving thereby the precision of measurement of its displacement. This in turn results in improved precision in the reported differential refractive index and in the calculation of the differential refractive index increment dn / dc . Integrating the detector array into the flow cell structure of the parent case results in a detector of exceptional sensitivity and range for sample quantities far smaller than required by conventional differential refractometers.

摘要翻译： 公开了一种结合光电探测器阵列的改进的差分折射计。 使用多元件照片阵列为测量差示折射率值提供了基础，其具有迄今为止无法实现的测量灵敏度和同时测量范围的组合。 在可达到的大动态范围内，探测器结构提供相同的灵敏度，而不考虑范围内的偏转。 透射光束被调整以提供阵列处的光强度的空间变化，从而提高其位移的测量精度。 这反过来导致报告的差示折射率和差示折射率增量dn / dc的计算中的精度提高。 将探测器阵列集成到母体情况的流动池结构中导致探测器具有出色的灵敏度和范围，以使样品量远小于传统差示折射仪所需的量。

公开(公告)号：EP1538435A3

公开(公告)日：2005-06-15

申请号：EP04013578.2

申请日：2004-06-09

申请人： Wyatt Technology Corporation

发明人： Larkin, Michael I.

IPC分类号： G01N21/41

CPC分类号： G01N21/4133

摘要： A cell for a walk-off refractometer is disclosed that permits measurement of the differential refractive index, DRI, between a sample fluid and a reference fluid. In addition, the new cell design permits the measurement of the refractive index, RI, of a fluid relative to the refractive index of the material comprising or surrounding the flow cell. Thus a single instrument may be used to measure separately the RI of a sample fluid and the DRI between a sample fluid and a reference fluid. The new flow cell contains two chambers, typical of a DRI instrument, but an asymmetric internal angle in either the sample or the reference chamber. By the provision of this structure, it is an objective of this invention to be able to measure the refractive index of a fluid relative to the refractive index of the material comprising the flow cell or relative to the medium surrounding the flow cell, either of which may be considered a measurement of the RI of the fluid. With the addition of mirror means, it is the further objective of this invention to improve its sensitivity. A further objective of the invention is to measure the asymmetric internal angle of the flow cell using well-characterized reference fluids.

摘要翻译： 公开了一种用于散步折射计的单元，其允许测量样本流体和参考流体之间的差示折射率DRI。 另外，新的电池设计允许测量流体的折射率RI相对于包含或围绕流动池的材料的折射率。 因此，可以使用单个仪器分别测量样本流体的RI和样本流体与参考流体之间的DRI。 新型流动池包含两个腔室，典型的DRI仪器，但样品或参比腔内都有不对称的内角。 通过提供这种结构，本发明的目的是能够测量流体的折射率相对于包括流动池的材料的折射率或相对于包围流动池的介质的折射率，其中任一个 可被认为是流体RI的测量。 通过添加反射镜装置，本发明的另一目的是提高其灵敏度。 本发明的另一目的是使用良好表征的参考流体来测量流动池的不对称内角。