公开(公告)号：EP2056823A2

公开(公告)日：2009-05-13

申请号：EP07814400.3

申请日：2007-08-23

申请人： Wyeth

发明人： BURSAVICH, Matthew, G. ,  LOMBARDI, Sabrina ,  GILBERT, Adam, M. ,  LAAKSO, Leif, Mark ,  KHAFIZOVA, Gulnaz ,  HOW, David, Brian ,  SABATINI, Joshua, James ,  SUM, Phaik-Eng ,  CLEMENS, Jeremy, J

IPC分类号： A61K31/47 ,  C07D215/16

CPC分类号： C07D215/28 ,  C07D215/26 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D409/10 ,  C07D417/10

摘要： The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

公开(公告)号：EP2303895A1

公开(公告)日：2011-04-06

申请号：EP09767711.6

申请日：2009-06-18

申请人： Wyeth LLC

发明人： PELLICCIARI, Roberto ,  MORONI, Flavio ,  GILBERT, Adam, M.

IPC分类号： C07D513/04 ,  A61K31/4745 ,  A61K31/5377 ,  A61P25/00 ,  A61P35/00

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/4745 ,  C07D513/04

摘要： The present invention relates to substituted thiazolyl- and oxazolyl- isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thiazolyl- and oxazolyl- isoquinolinones and to their use in treating various diseases and disorders.