公开(公告)号：EP1692117A1

公开(公告)日：2006-08-23

申请号：EP04813199.9

申请日：2004-12-07

申请人： Wyeth

发明人： SUM, Phaik-Eng ,  HOW, David, Brian ,  HOPPER, Darrin, William ,  VERA, Matthew, Douglas ,  SABATINI, Joshua, James

IPC分类号： C07D263/52 ,  C07C237/26 ,  A61K31/423 ,  A61P31/04

CPC分类号： C07C237/26 ,  A61K31/65 ,  C07C2603/46 ,  C07D263/52 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04

摘要： This invention provides compounds of the formula: wherein A', X and Y are defined in the specification. These compounds are useful as antibacterial agents.

摘要翻译： 本发明提供下式的化合物：其中A“，X和Y在说明书中定义，这些化合物可用作抗菌剂或可水解，得到9-（2-取代的氨基甲基羰基氨基）取代-6-脱甲基-6- 脱氧四环素衍生物。

公开(公告)号：EP1692117B1

公开(公告)日：2009-09-30

申请号：EP04813199.9

申请日：2004-12-07

申请人： Wyeth

发明人： SUM, Phaik-Eng ,  HOW, David, Brian ,  HOPPER, Darrin, William ,  VERA, Matthew, Douglas ,  SABATINI, Joshua, James

IPC分类号： C07D263/52 ,  C07C237/26 ,  A61K31/423 ,  A61P31/04

CPC分类号： C07C237/26 ,  A61K31/65 ,  C07C2603/46 ,  C07D263/52 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04

摘要： This invention provides compounds of the formula: wherein A', X and Y are defined in the specification. These compounds are useful as antibacterial agents.

公开(公告)号：EP2056823A2

公开(公告)日：2009-05-13

申请号：EP07814400.3

申请日：2007-08-23

申请人： Wyeth

发明人： BURSAVICH, Matthew, G. ,  LOMBARDI, Sabrina ,  GILBERT, Adam, M. ,  LAAKSO, Leif, Mark ,  KHAFIZOVA, Gulnaz ,  HOW, David, Brian ,  SABATINI, Joshua, James ,  SUM, Phaik-Eng ,  CLEMENS, Jeremy, J

IPC分类号： A61K31/47 ,  C07D215/16

CPC分类号： C07D215/28 ,  C07D215/26 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D409/10 ,  C07D417/10

摘要： The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

公开(公告)号：EP1919879A1

公开(公告)日：2008-05-14

申请号：EP06790037.3

申请日：2006-08-29

申请人： Wyeth

发明人： SUM, Phaik-Eng ,  MANSOUR, Tarek, Suhayl ,  HOW, David, Brian ,  HOPPER, Darrin, William ,  VERA, Matthew, Douglas ,  SABATINI, Joshua, James ,  SHIM, Jaechul

IPC分类号： C07D237/26 ,  C07D209/42 ,  C07C271/22 ,  C07D333/38 ,  C07D213/80 ,  C07D215/48 ,  A61K31/165 ,  C07D319/06

CPC分类号： C07D333/38 ,  C07C237/26 ,  C07C271/22 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/46 ,  C07C2603/74 ,  C07D207/416 ,  C07D209/42 ,  C07D213/81 ,  C07D213/82 ,  C07D215/48 ,  C07D307/68 ,  C07D307/84 ,  C07D317/34

摘要： This invention provides compounds of Formula (I) having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R4, R5, and R6 and A are defined in the specification are useful as chemical intermediates.

摘要翻译： 本发明提供具有如下结构的式（I）化合物或其药学上可接受的盐，其中R1，R2，R3和A定义为抗菌剂。 根据式（II）的化合物：其中Q，R 4，R 5和R 6和A在说明书中定义，可用作化学中间体。

公开(公告)号：EP1902014A2

公开(公告)日：2008-03-26

申请号：EP06787028.7

申请日：2006-07-11

申请人： Wyeth

发明人： SUM, Phaik-Eng ,  HOW, David, Brian ,  SABATINI, Joshua, James ,  XIANG, Jason, Shaoyun ,  IPEK, Manus ,  FEYFANT, Eric ,  MANSOUR, Tarek, Suhayl ,  TAM, Steve ,  SKOTNICKI, Jerauld, Stanley

IPC分类号： C07C237/22

CPC分类号： C07D213/82 ,  C07B2200/07 ,  C07C231/16 ,  C07C233/83 ,  C07C235/84 ,  C07C237/22 ,  C07C237/42 ,  C07C259/06 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2603/18 ,  C07C2603/74 ,  C07D213/38 ,  C07D239/26 ,  C07D239/42 ,  C07D277/30 ,  C07D307/52 ,  C07D307/68 ,  C07D307/79 ,  C07D307/85 ,  C07D317/58 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28 ,  C07D333/38 ,  C07D409/04

摘要： The present invention relates to compounds of the formula (I), which are modulators of metalloproteinase activity. and pharmaceutically acceptable salts thereof, wherein W is -C(O)-, -OC(O)-, -NHC(O)-, -C(O)O-, Or -C(O)NH-; R1 is phenyl, heteroaryl, biphenyl, bicyciic aryi, tricyclic aryl, bicyclic heteroaryl. or tricyclic heteroaryl, each optionally substituted with one or more of R5 or R6, and when Ri is substituted with more than one of R5 or Re, the substituents can be identical or different; R2 is hydrogen, (C1 -C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, -(CH2)nR11 , -OH, or -0-(C1-C6) alkyl; R3 is -CO2H, -CONH2, -CONHOH, -CONHSO2R7, tetrazole, -SO2NHR7, -SO3H, -PO(OH)NH2, -PO(OH)OR7, -CONHR7, -COOR7, an acid mimetic group, or a 5 or 6-membered heterocycloalkyl or heteroaryl containing 1 to 4 heteroatoms selected from O, N, S; R4 is -CO2H, -CONH2, -(CH2)nOR7, or -CONR9R10;

摘要翻译： 本发明涉及金属蛋白酶活性的调节剂。