公开(公告)号：EP1732887A1

公开(公告)日：2006-12-20

申请号：EP05730271.3

申请日：2005-03-29

申请人： Wyeth

发明人： KIM, Callain, Younghee ,  MAHANEY, Paige, Erin ,  TRYBULSKI, Eugene, John ,  ZHANG, Puwen ,  TEREFENKO, Eugene, Anthony ,  MCCOMAS, Casey, Cameron ,  MARELLA, Michael, Anthony ,  COGHLAN, Richard, Dale ,  HEFFERNAN, Gavin, David ,  COHN, Stephen, Todd ,  VU, An, Thien ,  SABATUCCI, Joseph, Peter ,  YE, Fei

IPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D265/36 ,  C07D241/42 ,  C07D235/06 ,  C07D471/04 ,  A61K31/4045 ,  A61P15/10

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D235/06 ,  C07D241/42 ,  C07D265/36 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formula (I): or a pharmaceutically acceptable salt thereof; wherein: the dotted line between Y and Z represents an optional double bond; the dotted line between the two R4 groups represents an optional heterocyclic ring of 4 to 6 ring atoms that may be formed between the two R4 groups, together with the nitrogen through which they are attached; Y is N, CR6, or C=O; Z is N, CR7, CR5, or C(R5)2; R2 is aryl substituted with 0-3 R1 or heteroaryl substituted with 0-3 R1; R3 is H or C1-C4 alkyl; n is an integer form 0 to 4; x is an integer from 1 to 2; and the other substituents are defined in the claims; compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected form the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

公开(公告)号：EP1620102A2

公开(公告)日：2006-02-01

申请号：EP04750987.2

申请日：2004-04-30

申请人： Wyeth

发明人： CAGGIANO, Thomas, J. ,  BRAZZALE, Antony, A. ,  MOORE, William, Jay ,  KIM, Callain, Younghee

IPC分类号： A61K31/496 ,  C07C255/19 ,  C07D295/185 ,  C07D213/74 ,  C07D211/82 ,  C07D211/18 ,  C07D209/08 ,  C07D217/16 ,  C07D205/04 ,  C07D215/14 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07C323/62 ,  C07C255/41 ,  C07C2601/14 ,  C07D211/34 ,  C07D215/14 ,  C07D295/192 ,  C07D401/04

摘要： This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

公开(公告)号：EP1620102B1

公开(公告)日：2008-12-24

申请号：EP04750987.2

申请日：2004-04-30

申请人： Wyeth

发明人： CAGGIANO, Thomas, J. ,  BRAZZALE, Antony, A. ,  MOORE, William, Jay ,  KIM, Callain, Younghee

IPC分类号： A61K31/496 ,  C07C255/19 ,  C07D295/185 ,  C07D213/74 ,  C07D211/82 ,  C07D211/18 ,  C07D209/08 ,  C07D217/16 ,  C07D205/04 ,  C07D215/14 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07C323/62 ,  C07C255/41 ,  C07C2601/14 ,  C07D211/34 ,  C07D215/14 ,  C07D295/192 ,  C07D401/04

摘要： This invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

摘要翻译： 本发明提供了可用于治疗疾病的炎症成分的式I化合物或其药学上可接受的盐，并且特别可用于治疗动脉粥样硬化，心肌梗塞，充血性心力衰竭，炎症性肠病，关节炎，II型糖尿病， 和自身免疫性疾病如多发性硬化和类风湿性关节炎。

公开(公告)号：EP1732887B1

公开(公告)日：2008-01-09

申请号：EP05730271.3

申请日：2005-03-29

申请人： Wyeth

发明人： KIM, Callain, Younghee ,  MAHANEY, Paige, Erin ,  TRYBULSKI, Eugene, John ,  ZHANG, Puwen ,  TEREFENKO, Eugene, Anthony ,  MCCOMAS, Casey, Cameron ,  MARELLA, Michael, Anthony ,  COGHLAN, Richard, Dale ,  HEFFERNAN, Gavin, David ,  COHN, Stephen, Todd ,  VU, An, Thien ,  SABATUCCI, Joseph, Peter ,  YE, Fei

IPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D265/36 ,  C07D241/42 ,  C07D235/06 ,  C07D471/04 ,  A61K31/4045 ,  A61P15/10

CPC分类号： C07D209/08 ,  C07D209/30 ,  C07D209/42 ,  C07D235/06 ,  C07D241/42 ,  C07D265/36 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formula (I): or a pharmaceutically acceptable salt thereof; wherein: the dotted line between Y and Z represents an optional double bond; the dotted line between the two R4 groups represents an optional heterocyclic ring of 4 to 6 ring atoms that may be formed between the two R4 groups, together with the nitrogen through which they are attached; Y is N, CR6, or C=O; Z is N, CR7, CR5, or C(R5)2; R2 is aryl substituted with 0-3 R1 or heteroaryl substituted with 0-3 R1; R3 is H or C1-C4 alkyl; n is an integer form 0 to 4; x is an integer from 1 to 2; and the other substituents are defined in the claims; compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected form the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

公开(公告)号：EP1931631A1

公开(公告)日：2008-06-18

申请号：EP06804032.8

申请日：2006-09-27

申请人： Wyeth

发明人： MAHANEY, Paige, Erin ,  HEFFERNAN, Gavin, David ,  COGHLAN, Richard, D. ,  COHN, Stephen, Todd ,  KIM, Callain, Younghee ,  JENKINS, Douglas, John ,  MARELLA, Michael, Anthony ,  MCCOMAS, Casey, Cameron ,  SABATUCCI, Joseph, Peter ,  TEREFENKO, Eugene, Anthony ,  TRYBULSKI, Eugene, John ,  VU, An, Thien ,  YE, Fei ,  ZHANG, Puwen

IPC分类号： C07D209/08 ,  C07D209/96 ,  C07D209/12 ,  C07D471/04 ,  C07D241/42 ,  C07D209/34 ,  C07D235/26 ,  A61K31/4045 ,  A61K31/437 ,  A61K31/517 ,  A61P15/10 ,  A61P1/04 ,  A61P13/02 ,  A61P25/04

CPC分类号： C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/34 ,  C07D209/96 ,  C07D235/26 ,  C07D241/42 ,  C07D401/12 ,  C07D471/04

摘要： The present invention is directed to phenylaminopropanol derivatives of formulae (I), (II), and (III); or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.