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公开(公告)号:EP1175398B1
公开(公告)日:2007-07-11
申请号:EP00930289.4
申请日:2000-05-01
申请人: Wyeth
发明人: FENSOME, Andrew , MILLER, Lori, L. , ULLRICH, John, W. , BENDER, Reinhold, H., W. , ZHANG, Puwen , WROBEL, Jay, E. , ZHI, Lin , JONES, Todd, K. , TEGLEY, Christopher, M. , EDWARDS, James, P.
IPC分类号: C07D209/34 , A61K31/40 , A61P5/00 , C07D491/10 , C07D209/96 , C07D401/04 , C07D409/04 , C07D405/04 , C07D403/04 , C07D317/00 , C07D319/00 , C07D311/00 , C07D209/00
CPC分类号: C07D209/34 , C07D209/96 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D491/10
摘要: This invention comprises compounds of formula (I), which are antagonists of the progesterone receptor, their preparation and utility.
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2.
公开(公告)号:EP1692111A2
公开(公告)日:2006-08-23
申请号:EP04813688.1
申请日:2004-12-10
发明人: COLLINI, Michael, D. , SINGHAUS, Robert, R., Jr. , HU, Baihua , JETTER, James, W. , MORRIS, Robert, L. , KAUFMAN, David, H. , MILLER, Christopher, P. , ULLRICH, John, W. , UNWALLA, Rayomand, J. , WROBEL, Jay, E. , QUINET, Elaine , NAMBI, Ponnal , BERNOTAS, Ronald, C. , ELLOSO, Merle
IPC分类号: C07D215/00
CPC分类号: C07D401/04 , C07D215/14 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/12
摘要: This invention provides compounds of formula (I) that are useful in the treatment or inhibition of LXR mediated diseases.
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公开(公告)号:EP1175397B1
公开(公告)日:2004-08-18
申请号:EP00930201.9
申请日:2000-05-01
发明人: ULLRICH, John, W. , FENSOME, Andrew , ZHI, Lin , JONES, Todd, K. , WROBEL, Jay, E. , TEGLEY, Christopher, M. , EDWARDS, James, P.
IPC分类号: C07D209/08 , A61K31/404 , A61P5/36
CPC分类号: C07D209/08
摘要: A compound of formula (I) and pharmaceutical compositions thereof useful as progesterone receptor antagonist wherein: R1 and R2 are H, OH, OAc, alkylaryl, alkylheteroaryl, 1-propynyl, optionally substituted alkyl, O(alkyl), aryl, heteroaryl; or R1 and R2 are joined to form a ring, a double bond to CMe2; C(cycloalkyl), O, C(cycloether); R3 = H, OH, NH2, CORA, or optionally substituted alkenyl or alkynyl; RA = H, optionally substituted alkyl, alkoxy, aminoalkyl; R¿4? = H, halo, CN, NH2, optionally substituted alkyl, alkoxy, or aminoalkyl; R5 = optionally substituted phenyl, a 5- or 6-membered heterocycle; a 4- or 7-substituted indole or a substituted benzothiophene.
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