公开(公告)号：EP2061776A1

公开(公告)日：2009-05-27

申请号：EP07862811.2

申请日：2007-12-12

申请人： Wyeth

发明人： MC COMAS, Casey Cameron ,  COHN, Stephen Todd ,  CRAWLEY, Matthew L. ,  FENSOME, Andrew ,  GOLDBERG, Joel Adam ,  JENKINS, Douglas John ,  KIM, Callain Younghee ,  MAHANEY, Paige Erin ,  MANN, Charles William ,  MARELLA, Michael Anthony ,  O'NEILL, David John ,  SABATUCCI, Joseph P. ,  TEREFENKO, Eugene Anthony ,  TRYBULSKI, Eugene John ,  VU, An Thien ,  WOODWORTH, Richard Page Jr. ,  ZHANG, Puwen

IPC分类号： C07D285/14 ,  C07D417/04 ,  C07D417/06

CPC分类号： C07D417/04 ,  C07D285/14 ,  C07D417/06

摘要： The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

公开(公告)号：EP1628961A1

公开(公告)日：2006-03-01

申请号：EP04752218.0

申请日：2004-05-13

申请人： Wyeth

发明人： VU, An Thien ,  COHN, Stephen, Todd ,  MEWSHAW, Richard Eric

IPC分类号： C07D215/20 ,  C07D409/04 ,  C07D417/04 ,  C07D401/04 ,  A61K31/47 ,  A61K31/407

CPC分类号： C07D215/20 ,  C07D401/04 ,  C07D413/04

摘要： This invention provides estrogen receptor modulators of formula: (I), having the structure wherein, R1, R2, R3, R4, R5 and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.