公开(公告)号：EP2064240A2

公开(公告)日：2009-06-03

申请号：EP07842719.2

申请日：2007-09-18

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  DESJARLAIS, John R. ,  KARKI, Sher Bahadur ,  LAZAR, Gregory Alan ,  MUCHHAL, Umesh S. ,  NGUYEN, Duc-hanh Thi ,  RICHARDS, John O.

IPC分类号： C07K16/00

CPC分类号： C07K16/2896 ,  A61K31/454 ,  A61K31/573 ,  A61K31/69 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/92

摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibodythat alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

公开(公告)号：EP3930850A1

公开(公告)日：2022-01-05

申请号：EP20715585.4

申请日：2020-02-28

申请人： Xencor, Inc.

发明人： RASHID, Rumana ,  MUCHHAL, Umesh S. ,  MOORE, Gregory ,  NISTHAL, Alex ,  CHU, Seung ,  LEE, Sung-Hyung ,  KIM, Yoon Kyung

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  A61K39/395 ,  A61K39/00 ,  C07K16/00