公开(公告)号：EP1636256A2

公开(公告)日：2006-03-22

申请号：EP04785771.9

申请日：2004-03-30

申请人： Xencor, Inc.

发明人： AGUINALDO, Anna Marie ,  BEYNA, Amelia, Joy ,  CHO, Ho, Sung ,  DESJARLAIS, John, Rudolph ,  MARSHALL, Shannon, Alicia ,  MUCHHAL, Umesh ,  VILLEGAS, Michael, Francis, Aquino ,  ZHUKOVSKY, Eugene ,  QUESENBERRY, Michael, Stephen

IPC分类号： C07K14/415 ,  C07K14/565 ,  C07K14/56

CPC分类号： C07K14/565 ,  C07K14/555 ,  C07K14/56

摘要： This invention relates to interferon variants with improved properties and methods for their use.

公开(公告)号：EP1606312A2

公开(公告)日：2005-12-21

申请号：EP04718010.4

申请日：2004-03-05

申请人： Xencor Inc.

发明人： DESJARLAIS, John, R. ,  ZHUKOVSKY, Eugene ,  THOMASON, Adam Read

IPC分类号： C07K14/705 ,  C12N15/63 ,  A61K38/00

CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K14/525 ,  C07K2319/00

摘要： The invention relates to BAFF protein mutants carrying at least one amino acid substitution at one position having dominant negative antagonist activity, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the BAFF protein mutants in the treatment of BAFF or APRIL-related disorders.

公开(公告)号：EP1581631A2

公开(公告)日：2005-10-05

申请号：EP03799328.4

申请日：2003-09-30

申请人： Xencor Inc.

发明人： AGUINALDO, Anna, Marie ,  BEYNA, Amelia, Joy ,  DESJARLAIS, John, Rudolph ,  MARSHALL, Shannon, Alicia ,  MUCHHAL, Umesh ,  VILLEGAS, Michael Francis Aquino ,  ZHUKOVSKY, Eugene ,  CHO, Ho Sung

IPC分类号： C12N1/00

CPC分类号： C07K14/56 ,  A61K38/00 ,  C07K14/555 ,  C07K14/565

摘要： The invention relates to interferon variants with improved properties and methods for their use.