公开(公告)号：EP1846035B1

公开(公告)日：2011-09-21

申请号：EP06734555.3

申请日：2006-02-08

申请人： Xenon Pharmaceuticals Inc.

发明人： KAMBOJ, Rajender ,  WINTHER, Michael ,  FRASER, Robert ,  CHAFEEV, Mikhail ,  CHOWDHURY, Sultan ,  FU, Jian-min ,  HOU, Duanjie ,  LIU, Shifeng ,  RAINA, Vandna ,  SEID BAGHERZADEH, Mehran ,  SVIRIDOV, Serguei ,  SADALUPURE, Kashinath ,  SUN Shaoyi ,  KODUMURU, Vishnumurthy ,  CHAKKA, Nagasree ,  ZHANG, Zaihui ,  ABREO, Melwyn ,  KONDRATENKO, Mikhail, A. ,  HARVEY, Daniel, F. ,  HUDSON, Cindy, J. ,  LI, Wenbao ,  TU, Chi ,  SUN, Sengen ,  HOLLADAY, Mark ,  GSCHWEND, Heinz

IPC分类号： A61K45/00 ,  A61P3/04

CPC分类号： A61K31/64 ,  A61K31/00 ,  A61K31/4439 ,  A61K38/28 ,  A61K45/06 ,  A61K2300/00

摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.

摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物疗法组合以治疗不利的体重增加。

公开(公告)号：EP1846035A2

公开(公告)日：2007-10-24

申请号：EP06734555.3

申请日：2006-02-08

申请人： XENON PHARMACEUTICALS INC.

发明人： KAMBOJ, Rajender ,  WINTHER, Michael ,  FRASER, Robert ,  CHAFEEV, Mikhail ,  CHOWDHURY, Sultan ,  FU, Jian-min ,  HOU, Duanjie ,  LIU, Shifeng ,  RAINA, Vandna ,  SEID BAGHERZADEH, Mehran ,  SVIRIDOV, Serguei ,  SADALUPURE, Kashinath ,  SUN Shaoyi ,  KODUMURU, Vishnumurthy ,  CHAKKA, Nagasree ,  ZHANG, Zaihui ,  ABREO, Melwyn ,  KONDRATENKO, Mikhail, A. ,  HARVEY, Daniel, F. ,  HUDSON, Cindy, J. ,  LI, Wenbao ,  TU, Chi ,  SUN, Sengen ,  HOLLADAY, Mark ,  GSCHWEND, Heinz

IPC分类号： A61K45/00 ,  A61P3/04

CPC分类号： A61K31/64 ,  A61K31/00 ,  A61K31/4439 ,  A61K38/28 ,  A61K45/06 ,  A61K2300/00

摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.