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公开(公告)号：EP1846035B1
公开(公告)日：2011-09-21
申请号：EP06734555.3
申请日：2006-02-08
发明人： KAMBOJ, Rajender , WINTHER, Michael , FRASER, Robert , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-min , HOU, Duanjie , LIU, Shifeng , RAINA, Vandna , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SADALUPURE, Kashinath , SUN Shaoyi , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , ZHANG, Zaihui , ABREO, Melwyn , KONDRATENKO, Mikhail, A. , HARVEY, Daniel, F. , HUDSON, Cindy, J. , LI, Wenbao , TU, Chi , SUN, Sengen , HOLLADAY, Mark , GSCHWEND, Heinz
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物疗法组合以治疗不利的体重增加。
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公开(公告)号：EP1799667B1
公开(公告)日：2013-03-20
申请号：EP05812357.1
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy
IPC分类号： C07D401/04
CPC分类号： C07D213/82
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公开(公告)号：EP1846035A2
公开(公告)日：2007-10-24
申请号：EP06734555.3
申请日：2006-02-08
发明人： KAMBOJ, Rajender , WINTHER, Michael , FRASER, Robert , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-min , HOU, Duanjie , LIU, Shifeng , RAINA, Vandna , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SADALUPURE, Kashinath , SUN Shaoyi , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , ZHANG, Zaihui , ABREO, Melwyn , KONDRATENKO, Mikhail, A. , HARVEY, Daniel, F. , HUDSON, Cindy, J. , LI, Wenbao , TU, Chi , SUN, Sengen , HOLLADAY, Mark , GSCHWEND, Heinz
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
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4.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS 审中-公开杂环衍生物及其作为硬脂酰COA脱氢酶抑制剂
公开(公告)号：EP1799664A1
公开(公告)日：2007-06-27
申请号：EP05816089.6
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , SVIRIDOV, Serguei , RAINA, Vandna , HOU, Duanjie , KODUMURU, Vishnumurthy , SEID BAGHERZADEH, Mehran
IPC分类号： C07D295/18 , A61K31/496
CPC分类号： C07D295/192
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651606A2
公开(公告)日：2006-05-03
申请号：EP04779655.2
申请日：2004-07-29
发明人： ABREO, Melwyn , HARVEY, Daniel, F. , GSCHWEND, Heinz, W. , LI, Wenbao , TU, Chi , KAMBOJ, Rajender , WINTHER, Michael, D. , KODUMURU, Vishnumurthy , HUDSON, Cindy, J. , KONDRATENKO, Mikhail, A. , LIU, Shifeng , RAINA, Vandna , SVIRIDOV, Serguei , ZHANG, Zaihui , SEID BAGHERZADEH, Mehran , SUN, Shaoyi
IPC分类号： C07D213/75
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is -O-, -N(R1)-, C(O) , S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2 , S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1) ; and V is C(O) , C(S) , C(O)N(R1)-, C(O)O-, S(O)2-, S(O)2N(R1)- or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了治疗哺乳动物，优选人的SCD介导的疾病或病症的方法，其中所述方法包括给予需要其的哺乳动物式（I）的化合物：其中：W为-O - ， - N （R1） - ，C（O），S（O）t; （其中t是0,1或2），N（R1）S（O）2，S（O）2N（R1），C（O）N（R1）或N（R1）C（O）N ）; （O），C（S），C（O）N（R 1） - ，C（O）O-，S（O）2 - ，S（O）2 N（R 1） - 或C ）H; 和x，y，R1，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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6.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS MEDIATORS OF STEAROYL-COA DESATURASE 审中-公开杂环衍生物及其作为硬脂酰COA脱氢酶调解员
公开(公告)号：EP1799668A1
公开(公告)日：2007-06-27
申请号：EP05815320.6
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SVIRIDOV, Serguei , SUN, Shaoyi , SEID BAGHERZADEH, Mehran , RAINA, Vandna , HOU, Duanjie , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy , CHAKKA, Nagasree
IPC分类号： C07D401/04 , C07D403/04 , A61K31/501
CPC分类号： C07D213/82 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1799667A1
公开(公告)日：2007-06-27
申请号：EP05812357.1
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy
IPC分类号： C07D401/04
CPC分类号： C07D213/82
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651606B1
公开(公告)日：2012-10-24
申请号：EP04779655.2
申请日：2004-07-29
发明人： ABREO, Melwyn , HARVEY, Daniel, F. , GSCHWEND, Heinz, W. , LI, Wenbao , TU, Chi , KAMBOJ, Rajender , WINTHER, Michael, D. , KODUMURU, Vishnumurthy , HUDSON, Cindy, J. , KONDRATENKO, Mikhail, A. , LIU, Shifeng , RAINA, Vandna , SVIRIDOV, Serguei , ZHANG, Zaihui , SEID BAGHERZADEH, Mehran , SUN, Shaoyi
IPC分类号： C07D213/75
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
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公开(公告)号：EP2073806B1
公开(公告)日：2012-02-15
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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公开(公告)号：EP2073806A2
公开(公告)日：2009-07-01
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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