-
1.发明公开METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES 有权方法为对ACYLOXYALKYLCARBAMATEN用于合成ACYLOXYALKYLTHIOCARBONATEN酶法动力学拆分
公开(公告)号：EP2250143A2
公开(公告)日：2010-11-17
申请号：EP09704177.6
申请日：2009-01-23
申请人： XenoPort, Inc.
IPC分类号： C07B57/00 , C07C269/04 , C07C329/06 , C07D207/46 , C12P41/00 , C07C271/22
CPC分类号： C07C329/06 , A61K31/325 , C07B2200/07 , C07B2200/13 , C07C271/22 , C12P11/00 , C12P41/005
摘要： Methods of enzymatically resolving acyloxyalkyl thiocarbonates useful in the synthesis of acyloxyalkyl carbamates are disclosed. These carbamates can be coupled to drugs containing amines such as R-baclofen or S-pregabalin.
-
2.发明授权METHOD FOR THE ENZYMATIC KINETIC RESOLUTION OF ACYLOXYALKYL THIOCARBONATES USED FOR THE SYNTHESIS OF ACYLOXYALKYL CARBAMATES 有权方法为对ACYLOXYALKYLCARBAMATEN用于合成ACYLOXYALKYLTHIOCARBONATEN酶法动力学拆分
公开(公告)号：EP2250143B1
公开(公告)日：2016-04-20
申请号：EP09704177.6
申请日：2009-01-23
申请人： XenoPort, Inc.
IPC分类号： C07B57/00 , C07C269/04 , C07C329/06 , C07D207/46 , C12P41/00 , C07C271/22 , A61K31/325 , C12P11/00
CPC分类号： C07C329/06 , A61K31/325 , C07B2200/07 , C07B2200/13 , C07C271/22 , C12P11/00 , C12P41/005
-
3.发明授权ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE 有权ACYLOXYALKYLCARBAMAT-PRODRUGS，SYNTHESEVERFAHREN UND ANWENDUNG
公开(公告)号：EP1660440B1
公开(公告)日：2012-02-22
申请号：EP04781926.3
申请日：2004-08-20
申请人： XenoPort, Inc.
发明人： GALLOP, Mark, A. , YAO, Fenmei , LUDWIKOW, Maria, J. , PHAN, Thu , PENG, Ge
IPC分类号： C07C271/22 , A61K31/195
CPC分类号： C07C271/22 , C07C2601/08 , C07C2601/14 , C07D213/79 , C07D307/30 , C07D333/38
摘要： The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof , methods of making prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
摘要翻译： 本文的公开内容通常涉及（.plusmn。）4氨基3（4氯苯基）丁酸及其类似物的酰氧基烷基氨基甲酸酯前药，其药物组合物，制备（.plusmn。）4氨基3（4氯苯基）丁酸 其酸和类似物，其用于（.plusmn。）4氨基3（4氯苯基）丁酸及其类似物的前药的方法及其用于治疗或预防常见疾病和/或病症如痉挛和/或酸的药物组合物 反流疾病。 本文的公开内容还涉及适于口服给药的（.plusmn）4氨基3（4氯苯基）丁酸及其类似物的氨基氧基烷基氨基甲酸酯产物及其缓释口服剂型。
-
4.发明公开
公开(公告)号：EP1660440A2
公开(公告)日：2006-05-31
申请号：EP04781926.3
申请日：2004-08-20
申请人： Xenoport, Inc.
发明人： GALLOP, Mark, A. , YAO, Fenmei , LUDWIKOW, Maria, J. , PHAN, Thu , PENG, Ge
IPC分类号： C07C271/22 , A61K31/195
CPC分类号： C07C271/22 , C07C2601/08 , C07C2601/14 , C07D213/79 , C07D307/30 , C07D333/38
摘要： The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof , methods of making prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±) 4 amino 3 (4 chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
-
-
-
搜索结果
4 条记录 (耗时 0.015 秒)
