公开(公告)号：EP3981786A1

公开(公告)日：2022-04-13

申请号：EP20809871.5

申请日：2020-05-22

申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

发明人： LUO, Wenxin ,  WEN, Can ,  XIANG, Xinchu ,  TANG, Jixian ,  WU, Yangtao ,  ZHANG, Tianying ,  YUAN, Quan ,  XIA, Ningshao

IPC分类号： C07K16/08 ,  A61K39/42 ,  A61P31/20

摘要： Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.