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16 条记录 (耗时 0.019 秒)

    ANTI-HEPATITIS B VIRUS ANTIBODIES AND USE THEREOF
    3.
    发明公开
    ANTI-HEPATITIS B VIRUS ANTIBODIES AND USE THEREOF 审中-公开

    公开(公告)号：EP3974446A1

    公开(公告)日：2022-03-30

    申请号：EP20808887.2

    申请日：2020-05-22

    申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

    发明人： LUO, Wenxin ,  JIANG, Yichao ,  YU, Chao ,  CHEN, Xiaoqing ,  TANG, Jixian ,  YUAN, Quan ,  ZHANG, Tianying ,  XIA, Ningshao

    IPC分类号： C07K16/08 ,  C12N15/13 ,  C12P21/00 ,  A61K39/42 ,  A61K31/20

    摘要： Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.

    NOVEL ANTI-HEPATITIS B VIRUS ANTIBODY AND USES THEREOF
    4.
    发明公开
    NOVEL ANTI-HEPATITIS B VIRUS ANTIBODY AND USES THEREOF 审中-公开

    公开(公告)号：EP3981786A1

    公开(公告)日：2022-04-13

    申请号：EP20809871.5

    申请日：2020-05-22

    申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

    发明人： LUO, Wenxin ,  WEN, Can ,  XIANG, Xinchu ,  TANG, Jixian ,  WU, Yangtao ,  ZHANG, Tianying ,  YUAN, Quan ,  XIA, Ningshao

    IPC分类号： C07K16/08 ,  A61K39/42 ,  A61P31/20

    摘要： Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.

    POLYPEPTIDES AND ANTIBODIES FOR TREATING HBV INFECTION AND RELATED DISEASES
    10.
    发明公开
    POLYPEPTIDES AND ANTIBODIES FOR TREATING HBV INFECTION AND RELATED DISEASES 审中-公开
    用于治疗HBV感染和相关疾病的多肽和抗体

    公开(公告)号：EP3308798A2

    公开(公告)日：2018-04-18

    申请号：EP17203789.7

    申请日：2013-06-06

    申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

    发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

    IPC分类号： A61K39/12

    摘要： The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositons for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

    摘要翻译： 本发明涉及用于治疗乙型肝炎病毒感染的表位肽（或其突变体），包含此类表位肽（或其突变体）和载体蛋白的重组蛋白，以及此类表位肽（或其突变体）和重组蛋白的用途。 本发明还涉及抗此类表位肽的抗体，产生所述抗体的细胞系及其用途。 此外，本发明涉及用于治疗或缓解与乙型肝炎病毒感染相关的一种或多种症状的疫苗或药物组合物，其分别包含根据本发明的重组蛋白或抗体。