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公开(公告)号:EP3974446A1
公开(公告)日:2022-03-30
申请号:EP20808887.2
申请日:2020-05-22
发明人: LUO, Wenxin , JIANG, Yichao , YU, Chao , CHEN, Xiaoqing , TANG, Jixian , YUAN, Quan , ZHANG, Tianying , XIA, Ningshao
摘要: Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.