公开(公告)号：EP1035844A1

公开(公告)日：2000-09-20

申请号：EP98958263.0

申请日：1998-12-01

申请人： Xyrofin Oy

发明人： VARGAS MUNITA, Sergio LuisInfectious Disease Div. ,  PEARSON, Julita ,  VIRKKI, Markku, Tapio ,  PEPPER, Tammy ,  SAUNDERS, David

IPC分类号： A61K31/045

CPC分类号： A61K9/0034 ,  A61F6/04 ,  A61K9/0053 ,  A61K31/045

摘要： The invention relates to the use of polyols such as xylitol for the preparation of a composition to be administered in the treatment or prophylaxis of mucosal yeast infection in mammals, as well as to preparations for use in the systemic or topical therapeutic or prophylactic treatment of mucosal yeast infections. The invention relates specifically but not solely to the combating of infections caused by Candida s.p. in mucosa in connection with exocrine glands of the mammalian body.

公开(公告)号：EP0906109B1

公开(公告)日：2001-06-27

申请号：EP97903227.3

申请日：1997-02-06

申请人： Xyrofin Oy

发明人： SAUNDERS, David ,  PEARSON, Julita

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  A61K31/70 ,  A61K2300/00

摘要： An aqueous laxative syrup is provided comprising one part by weight of lactulose and 0.66-1.5 parts by weight of a polyol selected from lactitol and/or maltitol. The syrup has a viscosity of 5-70 mPa.s. Preferably the polyol is lactitol. The syrup is less viscous than a lactulose-only syrup and has a pleasant balance of tastes between sweetness, acidity and bitterness. Furthermore, it does not suffer from an overly medicinal taste. This balance of characteristics makes the syrup pleasant to take and so improves patient compliance.

公开(公告)号：EP1064293A1

公开(公告)日：2001-01-03

申请号：EP99910395.5

申请日：1999-03-17

申请人： XYROFIN OY

发明人： HEIKKILÄ, Heikki ,  NYGREN, Johanna ,  SARKKI, Marja-Leena ,  GROS, H kan ,  EROMA, Olli-Pekka ,  PEARSON, Julita ,  PEPPER, Tammy

IPC分类号： C07H15/04

CPC分类号： C07H15/04

摘要： The present invention relates to a novel process for the crystallization of lactitol, to a particulate crystalline lactitol product having novel properties, to the use thereof as in foodstuffs, pharmaceuticals and oral hygiene products, as well as to special lactitol sweeteners. The process comprises: contacting a liquid containing dissolved lactitol with gas suspended fine solid particles containing microcrystalline lactitol; causing substantial removal of the solvent component of said liquid and allowing the resulting lactitol material to form an essentially solid composition of matter comprising a multitude of microcrystals of lactitol; and causing said lactitol composition to be conditioned during a further step to provide a product consisting essentially throughtout its entire structure of a multitude of microcrystals of lactitol agglomerated together in a random manner. The invention provides a crystalline lactitol product consisting essentially throughout its entire structure of a multitude of microcrystals of lactitol agglomerated together in a random manner.

公开(公告)号：EP0906109A1

公开(公告)日：1999-04-07

申请号：EP97903227.0

申请日：1997-02-06

申请人： Xyrofin Oy

发明人： SAUNDERS, David ,  PEARSON, Julita

IPC分类号： A61K31

CPC分类号： A61K31/7004 ,  A61K31/70 ,  A61K2300/00

摘要： An aqueous laxative syrup is provided comprising one part by weight of lactulose and 0.66-1.5 parts by weight of a polyol selected from lactitol and/or maltitol. The syrup has a viscosity of 5-70 mPa.s. Preferably the polyol is lactitol. The syrup is less viscous than a lactulose-only syrup and has a pleasant balance of tastes between sweetness, acidity and bitterness. Furthermore, it does not suffer from an overly medicinal taste. This balance of characteristics makes the syrup pleasant to take and so improves patient compliance.

摘要翻译： 提供含有1重量份乳果糖和0.66-1.5重量份选自乳糖醇和/或麦芽糖醇的多元醇的水性缓泻剂糖浆。 该糖浆的粘度为5-70mPa.s。 优选多元醇是乳糖醇。 该糖浆比仅含乳果糖的糖浆具有更低的粘性，并且在甜味，酸度和苦味之间具有令人愉快的平衡。 此外，它不会受到过度药用的味道。 这种特性的平衡使糖浆愉快地服用，并且因此改善了患者的依从性。

公开(公告)号：EP0844881A1

公开(公告)日：1998-06-03

申请号：EP96926415.0

申请日：1996-08-16

申请人： XYROFIN OY

发明人： OLINGER, Philip, M. ,  PEARSON, Julita ,  SAUNDERS, David

IPC分类号： A61K31 ,  A23L1 ,  A61K9 ,  A61K36 ,  A61P1 ,  A61K131

CPC分类号： A61K36/88 ,  Y10S514/892 ,  A61K2300/00

摘要： A combination bulk-forming and osmotic laxative is provided by combining a bulk-forming laxative in the form of psyllium hydrophilic mucilloid with an osmotic laxative such as lactitol. The addition of the osmotic laxative to the bulk-forming laxative with a binder solution and subsequent drying produces an improved laxative in granulate form which is directly compressible into tablets.

公开(公告)号：EP1173453A1

公开(公告)日：2002-01-23

申请号：EP00920768.9

申请日：2000-04-19

申请人： XYROFIN OY

发明人： HEIKKILÄ, Heikki ,  NYGREN, Johanna ,  SARKKI, Marja-Leena ,  GROS, Hakan ,  EROMA, Olli-Pekka ,  PEARSON, Julita ,  PEPPER, Tammy

IPC分类号： C07H15/04 ,  C07H15/08 ,  A23L1/236

CPC分类号： A23G1/40 ,  A23G3/38 ,  A23G3/42 ,  A23G4/10 ,  A23L27/34 ,  C07H15/04 ,  C07H15/08

摘要： The invention relates to a novel process for the crystallization of glucopyranosylalditols selected from the group consisting of 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM), 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS) and 1-O-α-D-glucopyranosyl-D-sorbitol (1,1-GPS). The process is performed by contacting a glucopyranosylalditol solution with particulate glucopyranosylalditol(s) suspended in a gas, drying the material to produce a multitude of microcrystals and conditioning the material into an agglomerated product. The invention also relates to a particulate crystalline glucopyranosylalditol product having novel properties, to the use thereof in confectionery, foodstuffs, pharmaceuticals and oral hygiene products, and to special products comprising the same.

摘要翻译： 本发明涉及一种结晶选自1-O-α-D-吡喃葡萄糖基-D-甘露糖醇（1,1-GPM），6-O-α-D-吡喃葡萄糖基-D （1,6-GPS）和1-O-α-D-吡喃葡萄糖基-D-山梨糖醇（1,1-GPS）。 该方法通过使吡喃葡萄糖基葡萄糖醇溶液与悬浮在气体中的微粒吡喃葡萄糖基二醇（一种或多种）接触来进行，将材料干燥以产生大量的微晶并将材料调节成团聚产物。 本发明还涉及具有新颖性质的颗粒状结晶吡喃葡萄糖基糖醇产品，涉及它们在糖食，食品，药物和口腔卫生产品中的用途，并涉及包含其的特殊产品。

公开(公告)号：EP1080060A2

公开(公告)日：2001-03-07

申请号：EP99925052.5

申请日：1999-05-17

申请人： XYROFIN OY

发明人： HEIKKILÄ, Heikki ,  NYGREN, Johanna ,  SARKKI, Marja-Leena ,  GROS, H kan ,  EROMA, Olli-Pekka ,  PEARSON, Julita ,  PEPPER, Tammy

IPC分类号： C07C29/78 ,  C07C31/18 ,  A23L1/236 ,  A23G3/00

CPC分类号： C07C29/78 ,  A23G3/346 ,  A23G2200/06 ,  A61K8/0241 ,  A61K8/60 ,  A61K9/2018 ,  A61Q11/00 ,  C07C31/18

摘要： The invention relates to a novel process for the crystallization of xylitol by contacting a xylitol solution with particulate xylitol suspended in a gas, drying the material to produce a multitude of microcrystals and conditioning the material into an agglomerated product. The invention also relates to a particulate crystalline xylitol product having novel properties, to the use thereof in confectionery, foodstuffs, pharmaceuticals and oral hygiene products, and to special products comprising the same.

公开(公告)号：EP0938301A1

公开(公告)日：1999-09-01

申请号：EP97919075.0

申请日：1997-09-16

申请人： Xyrofin Oy

发明人： PEARSON, Julita ,  OLINGER, Philip

IPC分类号： A23L1 ,  A61J3 ,  A61K9 ,  A61K47

CPC分类号： A61K9/2018 ,  Y10S514/952 ,  Y10S514/96

摘要： The invention relates to a directly compressible lactitol granulate and lactitol tablets made therefrom. The granulate comprises lactitol and a physiologically acceptable, non-cariogenic binder, which may be a non-cariogenic sugar alcohol, a polymerized reducing sugar, and alkali carboxymethylcellulose, a hydrogenated starch hydrolysate, a hydroxypropylcellulose, a physiologically acceptable cellulose derivative, polyvinylpyrrolidone, gum arabic or another physiologically acceptable gum. The preferred binder is lactitol. The invention also relates to a method of producing a directly compressible lactitol granulate, which can be used in tabletting contexts. The produced tablets exhibit high hardness and low friability. They are non-cariogenic and manifest the taste profile and metabolic properties of lactitol.