公开(公告)号：EP2740482A4

公开(公告)日：2015-03-04

申请号：EP12822146

申请日：2012-08-03

申请人： YAKULT HONSHA KK

发明人： OKUMURA TAKEKAZU ,  TERAI TOMOHIKO ,  NAKAO MASUMI ,  KANEKO KIMIYUKI ,  ITO MASAHIKO ,  MIYAZAKI KOUJI ,  YAMAJI KAZUAKI ,  TOCHIYA KAORU ,  HANADA NOBUHIRO ,  IMAI SUSUMU ,  NOMURA YOSHIAKI ,  BABA SHUNSUKE

IPC分类号： A61K35/74 ,  A23L1/30 ,  A61P1/02 ,  C12N1/20 ,  C12R1/225 ,  C12R1/46

CPC分类号： A61K8/99 ,  A23L2/52 ,  A23L29/065 ,  A23L33/135 ,  A61K9/2018 ,  A61K35/744 ,  A61K35/747 ,  A61Q11/00 ,  C12N1/20 ,  C12Q1/68 ,  C12R1/225 ,  C12R1/46

摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain. An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.

摘要翻译： 本发明提供能够抑制由口腔细菌产生挥发性硫化合物的新型乳酸菌株，在感染性心内膜炎中不具有致龋性，无致病作用，在口腔中是安全的，作为预防，改善 和/或通过使用细菌株治疗口腔疾病和不适。 一种用于预防和/或治疗口腔疾病的药物，其含有至少一种选自干酪乳杆菌，发酵乳杆菌，加氏乳杆菌和链球菌的至少一种乳酸菌，并具有以下所有性质（1）至 （6）：（1）不具有产生挥发性硫化合物（VSC）的能力; （2）不具有产生水不溶性葡聚糖的能力; （3）对牙齿表面和/或口腔具有粘附性; （4）对不良呼吸细菌和/或牙周病原体具有生长抑制作用; （5）感染性心内膜炎无致病作用; 和（6）没有致龋性。