公开(公告)号：EP1344528A4

公开(公告)日：2005-05-04

申请号：EP01271222

申请日：2001-12-06

申请人： YAKULT HONSHA KK

发明人： MIYAZAKI KOUJI ,  YOSHIKAWA SATOSHI ,  IIZUKA RYOKO ,  KINOSHITA TAKASHI ,  SAITO NAOHITO ,  CHIBA KATSUYOSHI ,  KONDO NAOMI ,  HANAMIZU TOMOKO

IPC分类号： A23K1/00 ,  A23L1/20 ,  A61K8/02 ,  A61K8/64 ,  A61K8/67 ,  A61K8/97 ,  A61K8/99 ,  A61K31/07 ,  A61K31/203 ,  A61K35/74 ,  A61K36/062 ,  A61K36/48 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C12P1/04 ,  A61K35/78 ,  A61K7/00 ,  A61K31/23

CPC分类号： C12P1/04 ,  A61K8/0212 ,  A61K8/645 ,  A61K8/671 ,  A61K8/97 ,  A61K31/07 ,  A61K31/203 ,  A61K36/062 ,  A61K36/48 ,  A61K2800/85 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  A61K2300/00

摘要： External skin preparations containing one or more members selected from among a fermentation product, which is obtained by treating a bean extract with a microorganism, vitamin A and its derivatives. By potentiating skin cells and accelerating the production of hyaluronic acid, these preparations exert effects of preventing and relieving skin chapping, improving keratin, moistening, and preventing and relieving skin tension failure and wrinkles, thereby efficaciously retarding skin aging.

公开(公告)号：EP2740482A4

公开(公告)日：2015-03-04

申请号：EP12822146

申请日：2012-08-03

申请人： YAKULT HONSHA KK

发明人： OKUMURA TAKEKAZU ,  TERAI TOMOHIKO ,  NAKAO MASUMI ,  KANEKO KIMIYUKI ,  ITO MASAHIKO ,  MIYAZAKI KOUJI ,  YAMAJI KAZUAKI ,  TOCHIYA KAORU ,  HANADA NOBUHIRO ,  IMAI SUSUMU ,  NOMURA YOSHIAKI ,  BABA SHUNSUKE

IPC分类号： A61K35/74 ,  A23L1/30 ,  A61P1/02 ,  C12N1/20 ,  C12R1/225 ,  C12R1/46

CPC分类号： A61K8/99 ,  A23L2/52 ,  A23L29/065 ,  A23L33/135 ,  A61K9/2018 ,  A61K35/744 ,  A61K35/747 ,  A61Q11/00 ,  C12N1/20 ,  C12Q1/68 ,  C12R1/225 ,  C12R1/46

摘要： Provided is a novel lactic acid bacterium strain which is capable of suppressing production of volatile sulfur compounds by oral bacteria, has no cariogenicity and no causative role in infective endocarditis, and is safe in an oral cavity, and provided is an agent for preventing, improving and/or treating oral diseases and discomforts by use of the bacterial strain. An agent for preventing and/or treating an oral disease, containing, as an active ingredient, at least one lactic acid bacterium selected from Lactobacillus crispatus, Lactobacillus fermentum, Lactobacillus gasseri, and Streptococcus mitis and having all of the following properties (1) to (6): (1) having no ability to produce a volatile sulfur compound (VSC); (2) having no ability to produce water-insoluble glucan; (3) having adhesiveness to a tooth surface and/or an oral cell; (4) having a growth inhibitory effect on a bad breath-causing bacterium and/or a periodontal pathogen; (5) having no causative role in infective endocarditis; and (6) having no cariogenicity.

摘要翻译： 本发明提供能够抑制由口腔细菌产生挥发性硫化合物的新型乳酸菌株，在感染性心内膜炎中不具有致龋性，无致病作用，在口腔中是安全的，作为预防，改善 和/或通过使用细菌株治疗口腔疾病和不适。 一种用于预防和/或治疗口腔疾病的药物，其含有至少一种选自干酪乳杆菌，发酵乳杆菌，加氏乳杆菌和链球菌的至少一种乳酸菌，并具有以下所有性质（1）至 （6）：（1）不具有产生挥发性硫化合物（VSC）的能力; （2）不具有产生水不溶性葡聚糖的能力; （3）对牙齿表面和/或口腔具有粘附性; （4）对不良呼吸细菌和/或牙周病原体具有生长抑制作用; （5）感染性心内膜炎无致病作用; 和（6）没有致龋性。

公开(公告)号：EP2586448A4

公开(公告)日：2014-01-15

申请号：EP11800786

申请日：2011-06-27

申请人： YAKULT HONSHA KK

发明人： MASUOKA NORIE ,  KANO MITSUYOSHI ,  MIYAZAKI KOUJI ,  SONE TOSHIRO

IPC分类号： A61K35/20 ,  A23C9/12 ,  A23L1/30 ,  A61K31/702 ,  A61K35/74 ,  A61P17/00 ,  A61P17/16

CPC分类号： A61K35/74 ,  A23L33/135 ,  A23V2002/00 ,  A61K31/702 ,  A61K35/20 ,  A61K35/744 ,  A61K35/745 ,  A23V2200/318 ,  A23V2200/3204

摘要： Disclosed is a skin property-improving agent which exerts excellent effects by oral administration. The skin property-improving agent for oral administration contains, as an active ingredient, a bacterium belonging to the genus Streptococcus and a bacterium belonging to the genus Bifidobacterium, or fermented milk containing the two bacteria.

公开(公告)号：EP1352640A4

公开(公告)日：2008-09-10

申请号：EP01270321

申请日：2001-12-10

申请人： YAKULT HONSHA KK

发明人： CHIBA KATSUYOSHI ,  SONE TOSHIRO ,  MIYAZAKI KOUJI ,  HANAMIZU TOMOKO ,  NISHISAKA FUKIKO ,  MATSUMOTO SACHIKO ,  AIYAMA RITSUO

IPC分类号： A61K8/96 ,  A61K8/00 ,  A61K8/02 ,  A61K8/06 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61K36/23 ,  A61K36/25 ,  A61K36/28 ,  A61K36/47 ,  A61K36/48 ,  A61K36/53 ,  A61K36/60 ,  A61K36/70 ,  A61K36/81 ,  A61P17/16 ,  A61P29/00 ,  A61P37/08 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A61K7/48 ,  A61K7/00

CPC分类号： A61Q19/08 ,  A61K8/97 ,  A61K2800/522 ,  A61K2800/782 ,  A61Q19/02

摘要： The present invention concerns a composition for retarding skin aging which contains an edible herb medicine or medicines found in Taiwan, in particular a plant extract or extracts having melanine formation-unhibiting, elastase-inhibiting, hyaluronidase-inhibiting, active oxygen- eliminating and/or radical-capturing type antioxidant activities, and a medicinally acceptable base and/or additives for external dermal application. The composition is useful in promoting skin whitening effects, maintaining the tension and elasticity of the skin, facilitating skin moistening and providing the skin with anti-inflammatory and/or anti-allergic properties.