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公开(公告)号:EP0185387B1
公开(公告)日:1988-12-14
申请号:EP85116361.8
申请日:1985-12-20
申请人: YALE UNIVERSITY
发明人: Satorelli, Alan C. , Shyam, krishnamurthy
IPC分类号: C07C143/825 , A61K31/18
CPC分类号: A61K31/15 , C07C311/49
公开(公告)号:EP0185387A1
公开(公告)日:1986-06-25
摘要: Compounds of the formula where R is methyl or 2-chloroethyl, and R' and R 2 are each an aromatic hydrocarbon, ring substituted aromatic hydrocarbon moiety, or an alkyl moiety. The compounds have been found to be alkylating agents having antineoplastic activity.