公开(公告)号：EP0933082A1

公开(公告)日：1999-08-04

申请号：EP99101561.1

申请日：1992-05-01

申请人： YALE UNIVERSITY ,  INDIANA UNIVERSITY FOUNDATION

发明人： Artavanis-Tsakonas, Spyridon ,  Muskavitch, Marc Alan Telander ,  Fehon, Richard Grant Dept. Biology-KBT Yale Univ. ,  Rebay, Ilaria Dept. of Biology-KBT Yale Univ. ,  Blaumueller, Christine Marie ,  Shepard, Scott Brockewell

IPC分类号： A61K38/17 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y10S530/839

摘要： The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.