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公开(公告)号：EP2292662A3
公开(公告)日：2011-07-13
申请号：EP10013178.8
申请日：1997-03-04
申请人： SCIOS INC.
IPC分类号： C07K16/26 , G01N33/577 , C07K14/58 , C07K7/00
CPC分类号： C07K14/58 , C07K16/26 , C07K2317/34 , Y10S530/839 , Y10S530/841
摘要： The invention relates to an in vitro method of diagnosing congestive heart disease by quantifying hBNP in a sample. The method comprises: contacting a sample of the biological fluid with a first antibody, wherein the first antibody is monospecifically reactive to an hBNP fragment; forming a complex comprising hBNP in the biological fluid, the first antibody and a second antibody, wherein the second antibody is immunoreactive with hBNP or the first antibody, and wherein the second antibody comprises a label; and determining the amount of hBNP in the sample by quantifying the label in the complex.
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公开(公告)号：EP0933082B1
公开(公告)日：2010-07-14
申请号：EP99101561.1
申请日：1992-05-01
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , C07K14/705 , C07K2319/00 , Y10S530/839
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公开(公告)号：EP0662092B1
公开(公告)日：2005-03-23
申请号：EP92913651.3
申请日：1992-04-22
申请人： THE UNITED STATES OF AMERICA, represented by the SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
CPC分类号： C07K14/475 , A61K38/00 , C07K16/22 , Y10S530/839
摘要： The present invention relates to a purified non-neuronal activity-dependent neurotrophic factor (ADNF) protein that increases the survival of spinal cord neuron cells, cerebral cortical cells and hippocampal neuron cells which has a molecular weight of 16,000 to 18,000 Daltons as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, and a basic pI of about 8.1. The protein of the present invention can be used in the treatment of neurological deficiencies and for the prevention of AIDS related neuronal cell death.
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公开(公告)号：EP0920501B1
公开(公告)日：2003-10-29
申请号：EP97935335.6
申请日：1997-08-07
IPC分类号： C12N15/12 , C07K14/475 , C07K16/22
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/827 , Y10S530/839 , Y10S530/855
摘要： Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.
摘要翻译： 公开了称为Neuritin的新多肽的DNA和氨基酸序列，其主要在脑的选定区域中表达。
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5.发明授权SUBSTANTIALLY PURE ZONULIN, A PHYSIOLOGICAL MODULATOR OF MAMMALIAN TIGHT JUNCTIONS 失效基本上纯AS“紧密连接”的连蛋白生理学哺乳动物调制器
公开(公告)号：EP0982988B1
公开(公告)日：2003-09-24
申请号：EP98919778.5
申请日：1998-04-28
发明人： FASANO, Alessio
CPC分类号： C07K14/4716 , A61K38/28 , A61K47/62 , C07K14/4705 , Y10S530/839 , Y10S530/844
摘要： A substantially pure mammalian protein, hereinafter "zonulin", that is a physiological modulator of mammalian tight junctions is disclosed, as well as methods for the use of the same.
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公开(公告)号：EP0721343B1
公开(公告)日：2002-10-16
申请号：EP94925903.0
申请日：1994-08-16
申请人： Syntex (U.S.A.) LLC
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/185 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/42 , Y10S530/839
摘要： Stable, aqueous pharmaceutical formulations of human nerve growth factor (NGF) in aqueous isotonic solutions, buffered to maintain the pH from about 4.5 to about 6.0, and optionnally containing a carrier such as human serum albumin are provided. Also provided are aqueous NGF formulations suitable for lyophilization and subsequent reconstitution in which rhNGF is admixed with sugars, optionally HSA, and buffer. The formulations are useful for the treatment of Alzheimer's disease and other neuronal disorders.
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公开(公告)号：EP0905143A3
公开(公告)日：2000-09-06
申请号：EP98307646.4
申请日：1998-09-21
CPC分类号： A61K9/1647 , A61K38/27 , C07K14/61 , Y10S530/839
摘要： The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.
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公开(公告)号：EP0946720A2
公开(公告)日：1999-10-06
申请号：EP97943514.0
申请日：1997-09-24
发明人： ANDERSON, David, J. , MA, Qiufu , SOMMER, Lukas
IPC分类号： C07K14
CPC分类号： C07K14/475 , Y10S530/839 , Y10S530/855
摘要： The invention relates to novel neurogenin proteins, nucleic acids and antibodies.
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公开(公告)号：EP0933082A1
公开(公告)日：1999-08-04
申请号：EP99101561.1
申请日：1992-05-01
发明人： Artavanis-Tsakonas, Spyridon , Muskavitch, Marc Alan Telander , Fehon, Richard Grant Dept. Biology-KBT Yale Univ. , Rebay, Ilaria Dept. of Biology-KBT Yale Univ. , Blaumueller, Christine Marie , Shepard, Scott Brockewell
IPC分类号： A61K38/17 , A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , C07K14/705 , C07K2319/00 , Y10S530/839
摘要： The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.
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公开(公告)号：EP0792288A1
公开(公告)日：1997-09-03
申请号：EP95939123.0
申请日：1995-11-13
申请人： AMGEN INC.
发明人： KINSTLER, Olaf, F. , YAN, Qiao
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/839
摘要： Derivatives of the neurotrophic factors BDNF and NT-3 have been prepared by attachment of these polypeptides to a water soluble polymer, for instance, polyethylene glycol.
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