利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.009 秒)

    Substituted azetidinone compounds, their preparation, and medicaments containing them
    1.
    发明公开
    Substituted azetidinone compounds, their preparation, and medicaments containing them 失效
    Substituierte Azetidinonverbindungen，deren Herstellung und ihre enthaltenden Arzneimittel。

    公开(公告)号：EP0171159A1

    公开(公告)日：1986-02-12

    申请号：EP85304532.6

    申请日：1985-06-25

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Tamura, Toshinari ,  Yoshida, Makoto ,  Tsukamoto, Shin-ichi ,  Iwamoto, Hidenori ,  Yamamoto, Minoru ,  Kagami, Soichi

    IPC分类号： C07K5/08 ,  C07D205/08 ,  A61K37/02

    CPC分类号： C07K5/0821 ,  C07D205/08 ,  C07D205/085 ,  C07F7/10

    摘要： Compounds of the following general formula (1) and salts thereof are useful pharmaceuticals having central nervous system activitv:
    wherein one of R 1 and R 2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or both represent a hydrogen atom or a lower alkyl group; R 3 represents a hydrogen atom or a group shown by formula:
    [wherein X represents

    (wherein R 5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group]; and R 4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula -CH 2 CO-A [wherein A represents an amino group or a group shown by formula
    (wherein X and Y are as defined above)]; provided that (a) at least one of R 3 and R 4 is other than a hydrogen atom and (b) when R 1 and R 2 are both hydrogen atoms at least R 4 is other than a hydrogen atom.

    摘要翻译： 下列通式（I）的化合物及其盐是具有中枢神经系统活性的有用药物：其中R 1和R 2之一表示取代的低级烷基，叠氮基， 氨基，低级酰氨基，巯基或低级烷硫基，另一方代表氢基，或二者均表示氢原子或低级烷基; R 3表示氢原子或由式表示的基团：... ... [其中X表示... ...或... ...（其中R 5表示氢原子或低级烷基 ），Y表示羟基，低级烷氧基，氨基，单 - 或二 - 低级烷基氨基]。 R 4表示氢原子，取代或未取代的低级烷基或式-CH 2 CO-A [其中A表示氨基或上述定义的基团]所示的基团]; 条件是（a）R 3和R 4中的至少一个不是氢原子，和（b）当R 1和R 2都是氢原子时，至少R 4是其它的 比氢原子。