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9 条记录 (耗时 0.017 秒)

    4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation
    5.
    发明公开
    4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation 失效
    4,5,6,7-四氢苯并咪唑衍生物和Herstellung。

    公开(公告)号：EP0376624A1

    公开(公告)日：1990-07-04

    申请号：EP89313415.5

    申请日：1989-12-21

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Ohta, Mitsuaki ,  Koide, Tokuo ,  Suzuki, Takeshi ,  Matsuhisa, Akira ,  Yanagisawa, Isao ,  Miyata, Keiji

    IPC分类号： C07D235/08 ,  A61K31/415 ,  C07D235/06

    CPC分类号： C07D235/06 ,  C07D235/08

    摘要： 4,5,6,7-Tetrahydrobenzimidazole derivatives (I) and salts thereof show 5-HT₃ antagonizing activity
    wherein
    R¹, R², R³ independently represent hydrogen atom, hydroxy group, a halogen atom, a lower alkyl group which may optionally be substituted with a halogen atom, a lower alkoxy group, a lower alkylthio group, an aralkyloxy group, an aryloxy group, a lower alkanoyl group, carboxy group, a lower alkoxycarbonyl group or nitro group; R⁴,R⁵ and R⁶ can each be a hydrogen atom or a lower alkyl group; and
    X is an oxygen atom or sulfur atom.

    摘要翻译： 4,5,6,7-四氢苯并咪唑衍生物（I）及其盐显示5-HT 3拮抗活性其中R 1，R 2，R 3独立地表示氢原子，羟基，卤素 低级烷氧基，低级烷硫基，芳烷氧基，芳氧基，低级烷酰基，羧基，低级烷氧基羰基或硝基的低级烷基; R 4，R 5和R 6各自可以是氢原子或低级烷基; X是氧原子或硫原子。 ð

    Oxazinobenzazole compounds
    8.
    发明公开
    Oxazinobenzazole compounds 失效
    恶嗪苯并唑化合物

    公开(公告)号：EP0500319A1

    公开(公告)日：1992-08-26

    申请号：EP92301320.5

    申请日：1992-02-18

    申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.

    发明人： Tsuzuki, Ryuji ,  Matsumoto, Yuzo ,  Matsuhisa, Akira ,  Yoden, Toru ,  Uchida, Wataru ,  Yanagisawa, Isao

    IPC分类号： C07D498/04 ,  C07D513/04 ,  A61K31/535

    CPC分类号： C07D513/04

    摘要： Oxazinobenzazole derivatives represented by the following general formula and salts thereof:
    wherein R 1 , R 2 , R 3 and R 9 are the same or different and selected from hydrogen atoms and C 1 -C 6 alkyl groups ; R 5 and R 6 form, in conjunction with the two adjacent carbon atoms, a 5- or 6-membered heterocyclic ring having at least two nitrogen atoms and optionally a further heteroatom selected from oxygen, sulphur and nitrogen ; and m is 0 or 1.
    The compounds are useful as antispasmodic medicaments.

    摘要翻译： 由以下通式表示的恶嗪并苯并唑衍生物及其盐：其中R1，R2，R3和R9相同或不同并选自氢原子和C1-C6烷基; R5和R6与两个相邻碳原子一起形成具有至少两个氮原子和任选另外的选自氧，硫和氮的杂原子的5-或6-元杂环; 并且m是0或1.该化合物可用作抗痉挛药物。