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公开(公告)号：EP0204440A1
公开(公告)日：1986-12-10
申请号：EP86303546.5
申请日：1986-05-09
IPC分类号： C07F7/10
CPC分类号： C07D205/08 , C07F7/10
摘要： The present invention relates to 1-substituted silyl-4-oxo-2-azetidine-carboxylic acid lower alkyl esters shown by general formula (I)
wherein R represents a lower alkyl group and ⓟ represents a substituted silyl group. These compounds are useful as intermediates for various drug syntheses.摘要翻译： 本发明涉及通式（I）所示的1-取代甲硅烷基-α-氧代-2-氮杂环丁烷 - 羧酸低级烷基酯
其中R表示低级烷基，P表示取代甲硅烷基。 这些化合物可用作各种药物合成的中间体。 -
公开(公告)号：EP0204440B1
公开(公告)日：1990-12-12
申请号：EP86303546.5
申请日：1986-05-09
IPC分类号： C07F7/10
CPC分类号： C07D205/08 , C07F7/10
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3.发明公开Dihydropyridine-3,5-dicarboxylic acid ester derivative isomers, their preparation, and pharmaceutical compositions containing them 失效二氢吡啶-3,5-二羧酸酯衍生物异构体，其制备和含有它们的药物组合物
公开(公告)号：EP0160451A3
公开(公告)日：1987-07-08
申请号：EP85302666
申请日：1985-04-16
发明人： Tamazawa, Kazuharu , Kojima, Tadao , Arima, Hideki , Murakami, Yukiyasu , Isomura, Yasuo , Okada, Minoru , Takanobu, Kiyoshi , Takenaka, Toichi
IPC分类号： C07D401/12 , A61K31/44 , C07B57/00
CPC分类号： C07D401/12 , C07D207/24 , C07D211/90
摘要： This invention provides new medicaments having coronary vasodilatory activity of superior degree and durability, these being diastereoisomer A of 2,6-dimethyl-4-(3- nittrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(benzylpyrrolidin-3-yl) ester 5-methyl ester, the melting point of the hydrochloride of this diastereoisomer A being 200 to 206°C (decomp.); the dextro-rotatory isomer of this diastereoisomer A; and pharmaceutically acceptable acid addition salts of these compounds. The medicament compounds of the invention can be separated from admixture with other isomers by various methods including chromatography and fractional crystallisation.
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4.发明授权Dihydropyridine-3,5-dicarboxylic acid ester derivative isomers, their preparation, and pharmaceutical compositions containing them 失效二氢吡啶-3,5-二羧酸酯衍生物异构体，其制备和含有它们的药物组合物
公开(公告)号：EP0160451B1
公开(公告)日：1991-08-28
申请号：EP85302666.4
申请日：1985-04-16
发明人： Tamazawa, Kazuharu , Kojima, Tadao , Arima, Hideki , Murakami, Yukiyasu , Isomura, Yasuo , Okada, Minoru , Takanobu, Kiyoshi , Takenaka, Toichi
IPC分类号： C07D401/12 , A61K31/44 , C07B57/00
CPC分类号： C07D401/12 , C07D207/24 , C07D211/90
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5.发明公开Dihydropyridine-3,5-dicarboxylic acid ester derivative isomers, their preparation, and pharmaceutical compositions containing them 失效3,5-二氢吡啶dicarboxylsäureester的衍生物的异构体，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0160451A2
公开(公告)日：1985-11-06
申请号：EP85302666.4
申请日：1985-04-16
发明人： Tamazawa, Kazuharu , Kojima, Tadao , Arima, Hideki , Murakami, Yukiyasu , Isomura, Yasuo , Okada, Minoru , Takanobu, Kiyoshi , Takenaka, Toichi
IPC分类号： C07D401/12 , A61K31/44 , C07B57/00
CPC分类号： C07D401/12 , C07D207/24 , C07D211/90
摘要： This invention provides new medicaments having coronary vasodilatory activity of superior degree and durability, these being diastereoisomer A of 2,6-dimethyl-4-(3- nittrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(benzylpyrrolidin-3-yl) ester 5-methyl ester, the melting point of the hydrochloride of this diastereoisomer A being 200 to 206°C (decomp.); the dextro-rotatory isomer of this diastereoisomer A; and pharmaceutically acceptable acid addition salts of these compounds. The medicament compounds of the invention can be separated from admixture with other isomers by various methods including chromatography and fractional crystallisation.
摘要翻译： 本发明提供具有优异的程度和耐久性，论文是2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸3-（苄非对映体A的冠状血管舒张活性的新药物 吡啶-3-基）酯5-甲基酯，此非对映体A为200〜206℃（分解的盐酸盐的熔点）; 此非对映异构A的右旋异构体; 和化合物论文的药学上可接受的酸加成盐。 本发明的药物化合物可以从混合有其它异构体通过各种方法包括色谱法和分步结晶来分离。
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