公开(公告)号：EP1541586A1

公开(公告)日：2005-06-15

申请号：EP03741500.7

申请日：2003-07-18

申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD. ,  Harigai, Masayoshi

发明人： TAKEUCHI, Masahiro, c/o Yamanouchi Pharma. Co Ltd. ,  YAMAJI, Noboru, c/o Yamanouchi Pharma. Co. Ltd. ,  TAKASAKI, Jun, c/o Yamanouchi Pharma. Co., Ltd. ,  AKAMATSU, Masahiko, c/o Yamanouchi Pharma. Co Ltd. ,  TSUNOYAMA, Kazuhisa, c/o Yamanouchi Pharma. Co Ltd ,  HARIGAI, Masayoshi

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N5/10

CPC分类号： C07K14/4713 ,  C12Q1/6883 ,  C12Q2600/158

摘要： It is disclosed that novel polypeptides which has enhanced expression levels in the synovial tissues of human chronic rheumatoid arthritis (RA) patients compared with the synovial tissues of human osteoarthritis (OA) patients, polynucleotides encoding the polypeptides, vectors comprising the polynucleotides, transformant cells comprising the vectors and an antibody against the polypeptide. It is also disclosed that polynucleotides specifically hybridizing with the polynucleotides and having at least 15 nucleotides, a detection method which is useful for RA diagnosis, and a detection kit which is useful for RA diagnosis.

摘要翻译： 已经公开了与人类骨关节炎（OA）患者的滑膜组织相比，在人类慢性类风湿性关节炎（RA）患者的滑膜组织中具有增强的表达水平的新型多肽，编码多肽的多核苷酸，包含多核苷酸的载体，转化体细胞包含 载体和针对多肽的抗体。 还公开了与多核苷酸特异性杂交并具有至少15个核苷酸的多核苷酸，可用于RA诊断的检测方法以及可用于RA诊断的检测试剂盒。