公开(公告)号：EP4316507A1

公开(公告)日：2024-02-07

申请号：EP22776151.7

申请日：2022-03-25

申请人： YD Life Science Co., Ltd. ,  Korea Research Institute of Bioscience and Biotechnology

发明人： RYU, Incheol ,  JEONG, Daeun ,  AN, Sihyeon ,  KIM, Seong Heon ,  KIM, Yunseon ,  RYOO, Kanghyun ,  LEE, Hyunseung ,  YOON, Dong-Oh ,  LEE, Myoungwoo ,  WON, Misun ,  IM, Joo-Young

IPC分类号： A61K38/44 ,  A61K38/16 ,  A61K38/19 ,  A61P35/00 ,  A23L33/17 ,  A23L33/195 ,  C12N15/63 ,  C12N9/02 ,  C07K14/55 ,  C07K14/54

摘要： The present invention relates to a composition for preventing or treating cancer, comprising a dual expression vector, and more specifically, to a method for effectively treating cancer by simultaneously inducing the actions of cancer metabolism drugs and cancer immunotherapy drugs by using a dual expression vector for simultaneously expressing an HIF-1α inhibitor and anticancer cytokines.

公开(公告)号：EP3053601B1

公开(公告)日：2017-11-08

申请号：EP14851311.2

申请日：2014-09-30

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： WON, Mi Sun ,  BAN, Hyun Seung ,  KIM, Bo Kyung ,  NAM, Soon Woo ,  LEE, Kyeong ,  LEE, Young-Ju ,  LEE, Hong-Sub ,  KIM, Dong Uk ,  PARK,Ki Cheol ,  OH, Kyoung-Jin ,  IM, Joo-Young

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61P35/00 ,  C12N9/02 ,  A61K38/44

CPC分类号： A61K38/44 ,  A61K48/005 ,  C12N7/00 ,  C12N9/004 ,  C12N2710/10043 ,  C12N2710/10071 ,  C12Y106/02002 ,  G01N33/57492 ,  G01N2333/90209

公开(公告)号：EP3053601A1

公开(公告)日：2016-08-10

申请号：EP14851311.2

申请日：2014-09-30

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： WON, Mi Sun ,  BAN, Hyun Seung ,  KIM, Bo Kyung ,  NAM, Soon Woo ,  LEE, Kyeong ,  LEE, Young-Ju ,  LEE, Hong-Sub ,  KIM, Dong Uk ,  PARK,Ki Cheol ,  OH, Kyoung-Jin ,  IM, Joo-Young

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61P35/00 ,  C12N9/02 ,  A61K38/44

CPC分类号： A61K38/44 ,  A61K48/005 ,  C12N7/00 ,  C12N9/004 ,  C12N2710/10043 ,  C12N2710/10071 ,  C12Y106/02002 ,  G01N33/57492 ,  G01N2333/90209

摘要： The present invention relates to a pharmaceutical composition for preventing and treating cancer, containing cytochrome b5 reductase 3 (cyb5R3) protein as an active ingredient. The expression of hypoxia-inducible factor-1 (HIF-1) is significantly reduced in cancer cells over-expressing cyb5R3 so as to inhibit the growth of cancer cells and effectively inhibit in vivo tumor growth and metastasis, and thus the cyb5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for preventing and treating cancer.

摘要翻译： 本发明涉及用于预防和治疗癌症，包含细胞色素b5还原酶3（CYB5R3）蛋白作为上活性成分的药物组合物。 缺氧诱导因子-1（HIF-1）的显着的癌细胞过度表达CYB5R3减小，以抑制癌细胞的生长和有效地抑制体内肿瘤生长和转移，并且因此CYB5R3基因或蛋白的表达 本发明的可作为用于预防和治疗癌症的药物组合物的活性成分是有用的。