专利检索 ap:("YEDA RESEARCH AND DEVELOPMENT CO., LTD." OR "Teva Pharmaceutical Industries, Inc." OR "Rappaport Faculty of Medicine AND Research Institute") AND inv:"AVIDAN, Nili" 第 1 页

1.

发明公开
MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE 审中-公开
标题翻译：乙酸格拉默相关标记的治疗作用

公开(公告)号：EP1891233A2

公开(公告)日：2008-02-27

申请号：EP06758673.5

申请日：2006-04-24

申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. , Teva Pharmaceutical Industries, Inc. , Rappaport Faculty of Medicine and Research Institute

发明人： LANCET, Doron , BECKMANN, Jacques , AVIDAN, Nili , BEN-ASHER, Edna , GOLDSTAUB, Dan , HAYARDENY, Liat , GROSSMAN, Iris , MILLER, Ariel , SINGER, Clara

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333

摘要： The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl and IL-12RB2.