公开(公告)号：EP0988274A1

公开(公告)日：2000-03-29

申请号：EP97949080.2

申请日：1997-12-25

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： BAR-TANA, Jacob

IPC分类号： C07C55/02 ,  A61K31/19 ,  A61K31/20 ,  A61K31/225

CPC分类号： C07C69/602 ,  C07C55/02

摘要： The present invention relates to a novel class of compounds for treating hyperlipidemia, obesity and impaired glucose tolerance/noninsulin dependent diabetes mellitus without adversely affecting energy metabolism, and pharmaceutical compositions comprising th e aforementioned compounds for the treatment of obesity, hyperlipidemia and maturity-onset diabetes.

公开(公告)号：EP0185080B1

公开(公告)日：1989-11-08

申请号：EP85903247.6

申请日：1985-06-15

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： BAR-TANA, Jacob ,  WITTE, Ernst-Christian ,  HAGENBRUCH, Bernd ,  PILL, Johannes ,  STEGMEIER, Karlheinz

IPC分类号： C07C50/02 ,  C07C57/34 ,  C07C55/28 ,  C07C57/42 ,  C07C59/84 ,  C07C69/618 ,  C07C69/608 ,  A61K31/20

CPC分类号： C07C57/42 ,  C07C55/28 ,  C07C55/32 ,  C07C57/13 ,  C07C57/34 ,  C07C57/38 ,  C07C59/245 ,  C07C59/305 ,  C07C59/84

摘要： alpha,omega-dicarboxylic acids having the general formula (I') in which: R1 and R2, which may be different or the same, represent a lower alkyl group which can be substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl being capable of substitution one or several times by hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C3-C7-cyclo-alkyl group or a phenyl group possibly substituted by hydroxy, halogen, lower alkyl or lower alkoxy, and X and Y, which may be different or the same, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxycarbonyl or carbamoyl, and Q represents non-ramified, saturated or unsaturated alkyl chain with 8-14 C atoms, which can be substituted, interrupted by hetero-atoms, and form part of a cyclic system, as well as their carboxylic acid derivatives in vivo, provided that when Q represents an unramified, saturated alkyl chain with 8-14 C atoms, and R1 and R2 represent methyl and Y represents hydrogen, X may not represent hydrogen, ethoxy-carbonyl, bromine, cyano or methyl, and if R1 and R2 represent methyl and X and Y hydrogen, then Q may not represent any formula (II) group. Process for their preparation and medicines containing these compounds, which have an anti-diabetic action and lower the level of lipids.