公开(公告)号：EP0185080B1

公开(公告)日：1989-11-08

申请号：EP85903247.6

申请日：1985-06-15

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： BAR-TANA, Jacob ,  WITTE, Ernst-Christian ,  HAGENBRUCH, Bernd ,  PILL, Johannes ,  STEGMEIER, Karlheinz

IPC分类号： C07C50/02 ,  C07C57/34 ,  C07C55/28 ,  C07C57/42 ,  C07C59/84 ,  C07C69/618 ,  C07C69/608 ,  A61K31/20

CPC分类号： C07C57/42 ,  C07C55/28 ,  C07C55/32 ,  C07C57/13 ,  C07C57/34 ,  C07C57/38 ,  C07C59/245 ,  C07C59/305 ,  C07C59/84

摘要： alpha,omega-dicarboxylic acids having the general formula (I') in which: R1 and R2, which may be different or the same, represent a lower alkyl group which can be substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl being capable of substitution one or several times by hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C3-C7-cyclo-alkyl group or a phenyl group possibly substituted by hydroxy, halogen, lower alkyl or lower alkoxy, and X and Y, which may be different or the same, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxycarbonyl or carbamoyl, and Q represents non-ramified, saturated or unsaturated alkyl chain with 8-14 C atoms, which can be substituted, interrupted by hetero-atoms, and form part of a cyclic system, as well as their carboxylic acid derivatives in vivo, provided that when Q represents an unramified, saturated alkyl chain with 8-14 C atoms, and R1 and R2 represent methyl and Y represents hydrogen, X may not represent hydrogen, ethoxy-carbonyl, bromine, cyano or methyl, and if R1 and R2 represent methyl and X and Y hydrogen, then Q may not represent any formula (II) group. Process for their preparation and medicines containing these compounds, which have an anti-diabetic action and lower the level of lipids.

公开(公告)号：EP0652750B1

公开(公告)日：1997-12-17

申请号：EP93915948.9

申请日：1993-07-17

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： PILL, Johannes ,  DOERGE, Liesel ,  STEGMEIER, Karlheinz

IPC分类号： A61K31/20

CPC分类号： A61K31/20

摘要： Compounds of α,w dicarboxylic acids of formula (I) in which X and Y, which may be the same or different, are hydrogen, halogen, C1-C6-alkyl, C1-C6-alkoxy, hydroxy, cyano, carboxyl, C1-C6-alkoxycarbonyl or carbamoyl, R1 and R2, which may the same or different, are hydrogen or C1-C6-alkyl, and Q is a linear saturated or unsaturated alkylene chain with 2-14 C atoms in which one or more C atoms may be replaced by cyclohexyl rings, phenyl or heterocycles, and their in vivo hydrolysable carboxylic acid derivatives for the production of medicaments with a fibrinogen reducing effect.