专利检索 ap:("YISSUM RESEARCH DEVELOPMENT COMPANY of the Hebrew University of Jerusalem") AND inv:"GERTZ, David, S." 第 1 页

1.

发明授权
PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION, PURIFICATION AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME 有权
标题翻译： PDGF受体激酶抑制化合物，生产，对其进行清洁和药物组合物含

公开(公告)号：EP1228072B1

公开(公告)日：2005-09-28

申请号：EP00973192.8

申请日：2000-11-02

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem

发明人： LEVITZKI, Alexander , GAZIT, Aviv , BANAI, Shmuel , GERTZ, David, S. , GOLOMB, Gershon , BOEHMER, Frank, D. , WALTENBERGER, Johannes

IPC分类号： C07D487/14 , A61K31/4188 , C07D487/04 , A61K31/4985 , A61K31/519 , A61P35/00

CPC分类号： C07D487/04

摘要： A preparation of a tyrphostin including a compound of a general formula (Compound I) or (Compound II), wherein, for (Compound I), the preparation is enriched either for R6 at position 6 or for R6 at position 7, or, for (Compound II), the preparation is enriched either for R6 at position 6 or for R6 at position 8.

2.

发明公开
PDGF RECEPTOR KINASE INHIBITORY COMPOUNDS, THEIR PREPARATION AND COMPOSITIONS 审中-公开
标题翻译： PDGF受体激酶抑制化合物，生产及组成

公开(公告)号：EP1036067A2

公开(公告)日：2000-09-20

申请号：EP98960526.6

申请日：1998-11-30

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY of the Hebrew University of Jerusalem

发明人： LEVITZKI, Alexander , GAZIT, Aviv , BANAI, Shmuel , GERTZ, David, S. , GOLOMB, Gershon

IPC分类号： C07D241/36 , C07D471/00 , A01N43/58

CPC分类号： C07D409/04 , C07D241/42 , C07D487/04

摘要： PDGF receptor kinase inhibitory compounds of the quinoxaline family, methods for their synthesis and containment in slow release pharmaceutical preparations, and their use for treatment of proliferative malignant and non-malignant diseases or disorders by local or systemic application. A compound according to the invention includes a tyrphostin of general formula (I), wherein R1 and R2 are each independently selected from the group consisting of alkyl, alkoxy, halogen, nitro and amine and Ar is selected from the group consisting of phenyl, ferrocene, thiophene, furane, pyrrole, indole, thiazole, imidazole and pyridine.