公开(公告)号：EP4271378A1

公开(公告)日：2023-11-08

申请号：EP22734853.9

申请日：2022-01-04

Applicant: Purdue Research Foundation

Inventor： LOW, Philip, S. ,  SRINIVASARAO, Madduri ,  LUO, Weichuan

IPC: A61K31/437 ,  A61K31/519 ,  C07D241/36 ,  C07D471/04

公开(公告)号：EP3980018A1

公开(公告)日：2022-04-13

申请号：EP20818408.5

申请日：2020-06-04

Applicant: The Rockefeller University

Inventor： KREEK, Mary Jeanne ,  REED, Brian ,  BUTELMAN, Eduardo ,  MILLER, Michael

IPC: A61K31/4985 ,  A61P25/30 ,  C07D241/36 ,  C07D311/02

公开(公告)号：EP3451064B1

公开(公告)日：2021-06-23

申请号：EP17789127.2

申请日：2017-03-17

Inventor： SHIMIZU Tomofumi ,  OKADA Hideki

IPC: G03G5/06 ,  G03G5/05 ,  C07C211/54 ,  C07D241/36

公开(公告)号：EP3569599A1

公开(公告)日：2019-11-20

申请号：EP18738618.0

申请日：2018-01-09

Applicant: Kyushu University National University Corporation ,  Nippon Soda Co., Ltd.

Inventor： YASUDA Takuma ,  FURUE Ryuhei ,  ISHIHARA Hiroyuki ,  FUKUSHIMA Yukio

IPC: C07D401/14 ,  C07D209/82 ,  C07D241/36 ,  C07D403/10 ,  C07D413/10 ,  C07D487/14 ,  H01L51/50

Abstract: Provided are: a dicyano N-heterocyclic compound represented by formula (I) (in the formula, R 3 represents an electron-donating group, and n represents the number of repetitions of the content in brackets and is 0 or 1), the compound having exceptional heat resistance and light emission characteristics; a light-emitting material; and a light-emitting element in which the same is used.

公开(公告)号：EP3247705B1

公开(公告)日：2019-11-20

申请号：EP16740634.7

申请日：2016-01-20

Applicant: Millennium Pharmaceuticals, Inc.

Inventor： FREEZE, Brian, Scott ,  GIGSTAD, Kenneth, M. ,  JANOWICK, David, A. ,  LEE, Hong, Myung ,  SHI, Zhan ,  SOUCY, Francois ,  VYSKOCIL, Stepan

IPC: C07D241/36 ,  C07D401/14 ,  C07D403/12 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/517 ,  C07D215/233 ,  C07D401/12 ,  C07D403/14 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

公开(公告)号：EP3492464A1

公开(公告)日：2019-06-05

申请号：EP18215386.6

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： BJORNSON, Kyla ,  CANALES, Eda ,  COTTELL, Jeromy, J. ,  KARKI, Kapil, Kumar ,  KATANA, Ashley, Anne ,  KATO, Darryl ,  KOBAYASHI, Tetsuya ,  LINK, John, O. ,  MARTINEZ, Ruben ,  PHILLIPS, Barton, W. ,  PYUN, Hyung-jung ,  SANGI, Michael ,  SCHRIER, Adam, James ,  SIEGEL, Dustin ,  TAYLOR, James, G. ,  TRAN, Chinh, Viet ,  TREJO MARTIN, Teresa, Alejandra ,  VIVIAN, Randall, W. ,  YANG, Zheng-Yu ,  ZABLOCKI, Jeff ,  ZIPFEL, Sheila

IPC: C07D403/14 ,  C07D241/36 ,  C07K5/08 ,  A61K31/10 ,  A61K38/06 ,  A61K38/21 ,  A61K31/40 ,  A61K31/47 ,  A61K31/506 ,  A61K31/519

Abstract: Intermediates, used for preparing inhibitors of the hepatitis C virus, of the following formulae are disclosed

公开(公告)号：EP3116862A1

公开(公告)日：2017-01-18

申请号：EP15760695.5

申请日：2015-03-06

Applicant: Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co. Ltd.

Inventor： WILLIAMS, Peter D. ,  MCCAULEY, John A. ,  BUNGARD, Christopher J. ,  BENNETT, David Jonathan ,  WADDELL, Sherman T. ,  MORRIELLO, Gregori J. ,  CHANG, Lehua ,  DWYER, Michael P. ,  HOLLOWAY, M. Katharine ,  CRESPO, Alejandro ,  CHU, Xin-Jie ,  WISCOUNT, Catherine ,  LOUGHRAN, H. Marie ,  MANIKOWSKI, Jesse J. ,  KEERTIKAR, Kartik M. ,  HU, Bin ,  ZHONG, Bin ,  JI, Tao

IPC: C07D281/10 ,  C07D241/36

CPC classification number: C07D513/08 ,  A61K31/554 ,  A61K45/06

Abstract: The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Abstract translation: 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。

公开(公告)号：EP2661428A1

公开(公告)日：2013-11-13

申请号：EP11851281.3

申请日：2011-12-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： BOYCE, Christopher W. ,  DEGRADO, Sylvia Joanna ,  CHEN, Xiao ,  QIN, Jun ,  MAZZOLA, Robert D Jr. ,  YU, Younong ,  MCCORMIC, Kevin D ,  PALANI, Anandan ,  XIAO, Dong ,  ASLANIAN, Robert George ,  WU, Jie ,  RAO, Ashwin Umesh ,  SILIPHAIVANH, Phieng ,  METHOD, Joe Lee ,  ZHANG, Hongjun ,  KELLEY, Elizabeth Helen ,  BROWN, William Colby ,  JIANG, Qin ,  GAUUAN, Jolicia Polivina ,  LEYHANE, Andrew J. ,  BIJU, Purakkattle Johny ,  DHONDI, Pawan K. ,  DONG, Li ,  FEVRIER, Salem ,  HUANG, Xianhai ,  VACCARO, Henry M.

IPC: C07D241/36 ,  A61K31/498

CPC classification number: C07D241/42 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D241/38 ,  C07D241/44 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10

Abstract: The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J
1 , J
2 , R
1 , R
2 , R
3 , R
22 , R
a , R
b , R
c , R
d , X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH
2 function.

公开(公告)号：EP2644688A3

公开(公告)日：2013-10-30

申请号：EP12175170.5

申请日：2012-07-05

Applicant: International Flavors & Fragrances Inc.

Inventor： BELKO, Robert P ,  JONES, Paul D ,  LEVORSE, Anthony T. ,  MONTELEONE, Michael G ,  NARULA, Anubhav P.S. ,  SCHIET, Franc T

IPC: C11B9/00 ,  A61Q13/00 ,  A61L9/02 ,  C07D231/00 ,  C07D233/00 ,  C07D235/00 ,  C07D239/00 ,  C07D239/74 ,  C07D241/00 ,  C07D241/36 ,  C07D261/00 ,  C07D263/00 ,  C07D265/04 ,  C07D265/28 ,  C07D275/00 ,  C07D277/00 ,  C07D279/02 ,  C07D279/04 ,  C11D3/50

CPC classification number: C11B9/0092 ,  A61K8/49 ,  A61K8/4953 ,  A61Q13/00 ,  C07D239/74 ,  C07D241/36 ,  C07D241/38 ,  C07D265/04 ,  C07D265/28 ,  C07D279/02 ,  C07D279/04 ,  C11B9/0096 ,  C11D3/50

Abstract: The present invention relates to novel pyrimidine derivatives and their use in perfume compositions. The novel pyrimidine derivatives of the present invention are represented by the following formula:

wherein m and n are integers that when m is 0, n is 1; when m is 1, n is 0 or 1; or when m is 2, n is 0;
wherein (CH)T" and (CH) n are each independently optionally substituted with a substituent selected from the group consisting of methyl and ethyl;
wherein X is selected from the group consisting of N, 0, and S; and
wherein R 1 and R z each independently represent H or a hydrocarbon group, or R 1 and R Z together represent a fused ring or a ring system,
with the proviso that when R 1 is H, R 2 is not H.

Abstract translation: 本发明涉及新的嘧啶衍生物及其在香料组合物中的用途。 本发明的新型嘧啶衍生物由下式表示：其中m和n是当m为0时n为1的整数; 当m是1时，n是0或1; 或者当m是2时，n是0; 其中（CH）T“和（CH）n各自独立地任选被选自甲基和乙基的取代基取代;其中X选自N，O和S;并且其中R1和Rz 各自独立地表示H或烃基，或者R1和RZ一起表示稠环或环体系，条件是当R1是H时，R2不是H.

公开(公告)号：EP2465860A1

公开(公告)日：2012-06-20

申请号：EP10808177.9

申请日：2010-08-06

Applicant: DIC Corporation

Inventor： KONDOU Hitoshi ,  SANO Yoshiyuki ,  TACHIKAWA Yutaka

IPC: C07D487/22 ,  C07D235/26 ,  C07D241/36 ,  C09B47/067 ,  C09B67/20

CPC classification number: C07D235/26 ,  C07D241/36 ,  C07D487/22 ,  C09B47/0673 ,  C09B47/0678

Abstract: Provided is a phthalocyanine compound which is halogen-free and which has a green hue, excellent resistance to organic solvents and acids, and high chroma. Also provided are a metal-free phthalocyanine compound or a metal phthalocyanine compound represented by specified general formula (1-1) or (1-2) and having a N,N'-disubstituted imidazolone structure or piperazinedione structure introduced therein, and a coloring composition including the compound and a synthetic resin. The phthalocyanine compound of the present invention exhibits a clear green color and is halogen-free, and is thus useful as a clear green pigment for coloring materials such as a coating material, plastic, a printing ink, rubber, leather, textile printing, a color filter, a jet ink, a heat transfer ink, etc.

Abstract translation: 提供一种无卤素的酞菁化合物，其具有绿色调，对有机溶剂和酸的耐受性优异，色度高。 还提供了一种无金属酞菁化合物或由指定的通式（1-1）或（1-2）表示并具有引入其中的N，N'-二取代的咪唑啉酮结构或哌嗪二酮结构的金属酞菁化合物， 包含该化合物和合成树脂的组合物。 本发明的酞菁化合物表现出清澈的绿色，是无卤素，因此可用作透明绿色颜料，用于着色材料如涂料，塑料，印刷油墨，橡胶，皮革，纺织品印花， 滤色器，喷墨油墨，传热油墨等