公开(公告)号：EP0436020A4

公开(公告)日：1992-03-25

申请号：EP88908326

申请日：1988-09-14

申请人： YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. ,  TAITO CO., LTD.

发明人： FUJITA, TETSURO ,  IKUMOTO, TAKESHI ,  SASAKI, SHIGEO ,  OKUMOTO, TAKEKI ,  CHIBA, KENJI, KOYAMADAI ELEGANT HOUSE NO. 105

IPC分类号： C07C229/22 ,  C07C229/30 ,  C07D307/33 ,  C12P13/00 ,  C12P17/04 ,  C07C101/30 ,  A61K31/20 ,  A61K31/365 ,  C07C101/34 ,  C07D307/32

CPC分类号： C07D307/33 ,  C07C229/22 ,  C07C229/30 ,  C12P13/001 ,  C12P13/02 ,  C12P17/04

摘要： This invention relates to an immunosuppressant comprising an effective amount of at least one compound selected from among compounds represented by formula (I), (wherein R represents a hydrogen atom or an acyl group, Y represents a carbonyl or hydroxymethylene group, and symbol ------- represents either a single bond or a double bond) and their lactones and a pharmaceutically acceptable carrier, a method of prophylaxis and treatment of immunorejection or autoimmune diseases comprising administering an effective amount of the above-described compound or its lactone, and a novel compound represented by formula (II) and its lactone.