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    Method of preparing a guanosine-group compound and an intermediate thereof
    2.
    发明公开
    Method of preparing a guanosine-group compound and an intermediate thereof 有权
    一种选自鸟苷的制备化合物的方法，以及它们的中间

    公开(公告)号：EP1138775A2

    公开(公告)日：2001-10-04

    申请号：EP01106745.1

    申请日：2001-03-17

    申请人： YUKI GOSEI KOGYO CO., LTD.

    发明人： Mikami, Yoichi ,  Matsumoto, Seiichiro ,  Hayashi, Yoshinori ,  Sato, Toyoki

    IPC分类号： C12P19/40

    CPC分类号： C12P19/40

    摘要： A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2'-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2'-deoxyguanosine is prepared.

    摘要翻译： 乙二醛 - 鸟苷类化合物是通过使乙二醛 - 鸟嘌呤与选定的核糖-1-磷酸中的任何一个和2-脱氧核糖-1-磷酸酯在嘌呤核苷磷酸化酶的存在下，或通过使乙二醛 - 鸟嘌呤与任何一种制备任一 选自尿苷，2'-脱氧尿苷和胸苷的，与磷酸根离子一起，在嘌呤核苷磷酸化酶和嘧啶核苷磷酸化酶的存在。 的乙二醛 - 鸟苷类化合物，然后通过碱，由此由......组成鸟苷和2'-脱氧鸟苷的鸟苷类化合物制备分解。

    Method of preparing purine nucleoside compound
    5.
    发明公开
    Method of preparing purine nucleoside compound 失效
    Verfahren zur Herstellung eine Purin-Nukleosid-Verbindung

    公开(公告)号：EP0896065A1

    公开(公告)日：1999-02-10

    申请号：EP98114169.0

    申请日：1998-07-29

    申请人： YUKI GOSEI KOGYO CO., LTD.

    发明人： Mikami, Yoichi ,  Matsumoto, Seiichiro ,  Yoshinaka, Shinjhi ,  Sunaga, Yonosuke ,  Hasegawa, Ayumi

    IPC分类号： C12P19/40 ,  C12N1/20

    CPC分类号： C12P19/40

    摘要： The present invention provides a method of preparing stably and at a high yield a purine nucleoside compound by utilizing an exchange reaction of a nucleic acid base which is carried out in the presence of an enzyme, and also provides a microorganism capable of producing uracil thymine dehydrogenase or dihydrouracil dehydrogenase. In preparing the purine nucleoside compound, a pyrimidine nucleoside compound and a purine base are subjected to a base exchange reaction in an aqueous solution containing phosphate ions in the presence of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase. The pyrimidine base formed by the base exchange reaction is converted by a microorganism or an enzyme derived from the microorganism into a compound incapable of acting as substrates of pyrimidine nucleoside phosphorylase and purine nucleoside phosphorylase so as to obtain a desired product of purine nucleoside compound.

    摘要翻译： 本发明提供了通过利用在酶的存在下进行的核酸碱基的交换反应来稳定且高产率地制备嘌呤核苷化合物的方法，并且还提供能够产生尿嘧啶胸腺嘧啶脱氢酶的微生物 或二氢尿嘧啶脱氢酶。 在制备嘌呤核苷化合物时，嘧啶核苷化合物和嘌呤碱在嘧啶核苷磷酸化酶和嘌呤核苷磷酸化酶的存在下，在含有磷酸根离子的水溶液中进行碱交换反应。 通过碱交换反应形成的嘧啶碱由微生物或源自微生物的酶转化为不能作为嘧啶核苷磷酸化酶和嘌呤核苷磷酸化酶底物的化合物，以获得所需的嘌呤核苷化合物产物。