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    Regulation of oncogenes by microRNAs
    3.
    发明公开
    Regulation of oncogenes by microRNAs 有权
    通过microRNA调节癌基因

    公开(公告)号：EP2338993A1

    公开(公告)日：2011-06-29

    申请号：EP10178401.5

    申请日：2005-09-02

    申请人： Yale University

    发明人： Slack, Frank J. ,  Johnson, Steven M. ,  Grosshans, Helge

    IPC分类号： C12N15/11 ,  A61K31/713 ,  A61K48/00 ,  A61P35/00

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  A61K38/00 ,  A61K41/00 ,  A61K45/06 ,  A61K48/00 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/141 ,  A61K2300/00

    摘要： Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.

    摘要翻译： 描述了调节人癌基因的天然存在的miRNA及其使用方法。 用于本文所述方法和组合物的合适核酸包括但不限于保留成熟miRNA和编码pri-miRNA的DNA的生物学活性的pri-miRNA，pre-miRNA，成熟miRNA或其变体的片段， miRNA，pre-miRNA，成熟miRNA，其片段或变体，或miRNA的调控元件。 将含有核酸的组合物给予需要治疗或预防癌症的至少一种症状或表现的患者。 在一个实施方案中，组合物以有效量施用以抑制一种或多种癌基因的基因表达。 还描述了用于治疗或预防至少一种癌症症状或表现的方法。

    Regulation of oncogenes by microRNAs
    8.
    发明公开
    Regulation of oncogenes by microRNAs 有权
    Regulierung von Onkogenen durch mikro-RNAs

    公开(公告)号：EP2338994A1

    公开(公告)日：2011-06-29

    申请号：EP10178429.6

    申请日：2005-09-02

    申请人： Yale University

    发明人： Slack, Frank J. ,  Johnson, Steven M. ,  Grosshans, Helge

    IPC分类号： C12N15/11 ,  A61K31/713 ,  A61K48/00 ,  A61P35/00 ,  C12N15/113

    CPC分类号： C12N15/1135 ,  A61K31/7088 ,  A61K38/00 ,  A61K41/00 ,  A61K45/06 ,  A61K48/00 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/141 ,  A61K2300/00

    摘要： Naturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not limited to, pri-miRNA, pre-miRNA, mature miRNA or fragments of variants thereof that retain the biological activity of the mature miRNA and DNA encoding a pri-miRNA, pre-miRNA, mature miRNA, fragments or variants thereof, or regulatory elements of the miRNA. The compositions containing nucleic acids are administered to a patient in need of treatment or prophylaxis of at least one symptom or manifestation of cancer. In one embodiment, the compositions are administered in an effective amount to inhibit gene expression of one or more oncogenes. Methods for treatment or prevention of at least one symptom or manifestation of cancer are also described.

    摘要翻译： 描述了调节人癌基因的天然存在的miRNA及其使用方法。 用于本文描述的方法和组合物的合适的核酸包括但不限于保留成熟miRNA的生物活性的pri-miRNA，前miRNA，成熟miRNA或其变体的片段，编码pri- miRNA，前miRNA，成熟miRNA，其片段或变体，或miRNA的调节元件。 将含有核酸的组合物施用于需要治疗或预防癌症至少一种症状或表现的患者。 在一个实施方案中，组合物以有效量施用以抑制一种或多种致癌基因的基因表达。 还描述了用于治疗或预防癌症的至少一种症状或表现的方法。