公开(公告)号：EP3250585B1

公开(公告)日：2019-08-14

申请号：EP16711899.1

申请日：2016-01-26

申请人： Yeda Research and Development Co., Ltd.

发明人： YONATH, Ada ,  EYAL, Zohar ,  MATZOV, Donna ,  ROZENBERG, Haim ,  ZIMMERMAN, Ella ,  BASHAN, Anat

IPC分类号： C07K14/31 ,  C30B29/58 ,  C07H17/08 ,  C07D263/20 ,  C07D211/54 ,  G16B15/00 ,  G16B30/00 ,  G16C20/50

公开(公告)号：EP3250585A1

公开(公告)日：2017-12-06

申请号：EP16711899.1

申请日：2016-01-26

申请人： Yeda Research and Development Co., Ltd.

发明人： YONATH, Ada ,  EYAL, Zohar ,  MATZOV, Donna ,  ROZENBERG, Haim ,  ZIMMERMAN, Ella ,  BASHAN, Anat

IPC分类号： C07K14/31 ,  C30B29/58 ,  G06F19/16

CPC分类号： C07K14/31 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08 ,  C07K2299/00 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60

摘要： A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.