公开(公告)号：EP3136951A1

公开(公告)日：2017-03-08

申请号：EP15786002.4

申请日：2015-04-30

申请人： Yeda Research and Development Co. Ltd. ,  Ministry of Health on Behalf of the Jerusalem Mental Health Center

发明人： HARMELIN, Alon ,  ISRAELI, David ,  KUZNETSOV, Yuri ,  KALCHENKO, Vyacheslav

IPC分类号： A61B5/00

CPC分类号： A61B5/0035 ,  A61B5/0042 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/02007 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/4064 ,  A61B2576/026 ,  G01N21/6456 ,  G01N21/84 ,  G01N2201/06113 ,  G01N2201/068

摘要： A method of transcranial brain optical imaging including obtaining a Laser Speckle (LS) image of cranial blood vessels of a subject, obtaining a Dynamic Fluorescence (DF) image of the cranial blood vessels of the subject, and combining the LS image and the DF image producing a combined color image which displays both structure of the cranial blood vessels and perfusion of blood along the cranial blood vessels. Related apparatus and methods are also described.

摘要翻译： 一种经颅脑光学成像方法，包括获得受试者颅血管的激光斑点（LS）图像，获得受试者颅血管的动态荧光（DF）图像，并组合LS图像和DF图像 产生组合的彩色图像，其显示颅血管的结构和沿着颅血管的血液灌注。 还描述了相关装置和方法。

公开(公告)号：EP2157911A2

公开(公告)日：2010-03-03

申请号：EP08751361.0

申请日：2008-05-15

申请人： Yeda Research And Development Co. Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

发明人： ISRAELI, David ,  MARDOR, Yael ,  VOLK, Talila

IPC分类号： A61B5/055 ,  G01R33/483 ,  A61K49/00

CPC分类号： A61B5/4848 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4836 ,  A61B5/743 ,  A61B2576/026 ,  A61K49/0004 ,  A61N2/006 ,  G01R33/5601 ,  G01R33/56366

摘要： A method of analyzing a blood-brain barrier of a subject is disclosed. A detectable dose of an MRI contrast agent is administered to the subject, and a plurality of magnetic resonance images of the subject's brain are acquired over a predetermined time-period. Two or more of the magnetic resonance images are compared thereamongst so as to determine variations in concentration of the contrast agent in the brain, and blood-brain barrier function is assessed based on the variations.