专利检索 ap:("Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.") AND inv:"BURSTAIN, Ido" 第 1 页

1.

发明公开
PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF 审中-公开

公开(公告)号：EP3331877A1

公开(公告)日：2018-06-13

申请号：EP16753709.1

申请日：2016-08-04

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： BEN NERIAH, Yinon , BRACHYA, Guy , BURSTAIN, Ido , MINZEL, Waleed , SNIR-ALKALAY, Irit , VACCA, Joseph , LI, Dansu

IPC分类号： C07D405/14 , C07D413/14 , C07D403/04 , A61K31/506 , A61P35/00

CPC分类号： A61K31/506 , A61P35/02 , C07D403/04 , C07D405/14 , C07D413/14

摘要： The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.