公开(公告)号：EP3331877A1

公开(公告)日：2018-06-13

申请号：EP16753709.1

申请日：2016-08-04

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： BEN NERIAH, Yinon ,  BRACHYA, Guy ,  BURSTAIN, Ido ,  MINZEL, Waleed ,  SNIR-ALKALAY, Irit ,  VACCA, Joseph ,  LI, Dansu

IPC分类号： C07D405/14 ,  C07D413/14 ,  C07D403/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： A61K31/506 ,  A61P35/02 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14

摘要： The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.

公开(公告)号：EP3102192A2

公开(公告)日：2016-12-14

申请号：EP15706542.6

申请日：2015-02-03

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： BEN-NERIAH, Yinon ,  MINZEL, Waleed ,  BRACHYA, Guy

IPC分类号： A61K31/00 ,  A61K31/506 ,  A61K35/12 ,  C12Q1/00 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/506 ,  A61K31/00 ,  A61K35/12 ,  A61K35/14 ,  A61K35/28 ,  C12N15/1137 ,  C12N2310/14 ,  G01N33/502 ,  G01N33/5073

摘要： A method of treating cancer in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a Casein kinase I alpha (CKIalpha) inhibitor, wherein the cancer is not associated with an Adenomatous polyposis coli (APC) mutation. Additional uses of CKI inhibitors are also disclosed.

摘要翻译： 公开了一种治疗受试者的癌症的方法。 该方法包括向受试者施用治疗有效量的酪蛋白激酶Iα（CKIα）抑制剂，其中所述癌症与腺瘤性息肉病大肠杆菌（APC）突变不相关。 还公开了CKI抑制剂的其它用途。