公开(公告)号：EP2560671A2

公开(公告)日：2013-02-27

申请号：EP11720887.6

申请日：2011-04-17

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center

发明人： GERTLER, Arieh ,  ELINAV, Eran ,  HALPERN, Zamir

IPC分类号： A61K38/16 ,  A61K38/22

CPC分类号： C07K14/5759 ,  A01K2217/00 ,  A61K31/05 ,  A61K31/575 ,  A61K38/22 ,  A61K38/2264 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K49/0008 ,  A61K2300/00

摘要： Leptin muteins, in particular leptin antagonists, with increased binding affinity to leptin receptor are provided. These compounds as well as pharmaceutical composition comprising them are useful for the treatment of any disorder in which a non-desirable or deleterious activity of endogenous leptin or an altered innate immune response is implicated.

公开(公告)号：EP2560671B1

公开(公告)日：2014-09-24

申请号：EP11720887.6

申请日：2011-04-17

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center

发明人： GERTLER, Arieh ,  ELINAV, Eran ,  HALPERN, Zamir

IPC分类号： A61K38/22 ,  A61P5/50 ,  A61P29/00 ,  A61P37/06 ,  A61P25/28 ,  A61P9/10

CPC分类号： C07K14/5759 ,  A01K2217/00 ,  A61K31/05 ,  A61K31/575 ,  A61K38/22 ,  A61K38/2264 ,  A61K38/28 ,  A61K45/06 ,  A61K47/60 ,  A61K49/0008 ,  A61K2300/00

公开(公告)号：EP3818529A2

公开(公告)日：2021-05-12

申请号：EP19752273.3

申请日：2019-07-08

申请人： Yeda Research and Development Co. Ltd ,  The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

发明人： SEGAL, Eran ,  ELINAV, Eran ,  HALPERN, Zamir

IPC分类号： G16B10/00 ,  G16H20/60 ,  G16H50/30 ,  C12Q1/689 ,  A23L33/135 ,  A61K35/741 ,  G16H10/40 ,  G16H50/20