公开(公告)号：EP1298139A2

公开(公告)日：2003-04-02

申请号：EP02021736.0

申请日：2002-09-25

申请人： Zeon Corporation

发明人： Sato, Takanori ,  Tsuzaki, Yoshinari ,  Esaki, Motoyuki ,  Dorsey, M. Kristi

IPC分类号： C07K14/08 ,  A61K39/12 ,  C12N15/86 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/55 ,  A61K2039/552 ,  C12N2710/16321 ,  C12N2720/10034 ,  Y10S424/816

摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype I strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.

摘要翻译： 本发明提供了通过存在编码IBDV特拉华变异株E的VP2（IBDV血清型I株）亚型的cDNA修饰的禽重组疱疹病毒。 本发明还提供了由VP2基因组成的禽类重组疱疹病毒，其中主要病毒是马立克氏病疫苗株，例如火鸡疱疹病毒。 包括本发明中描述的禽类重组病毒的家禽疫苗可诱导针对IBDV的各种不同亚型的鸡的保护性免疫。

公开(公告)号：EP1298139B1

公开(公告)日：2007-05-02

申请号：EP02021736.0

申请日：2002-09-25

申请人： ZEON CORPORATION

发明人： Sato, Takanori ,  Tsuzaki, Yoshinari ,  Esaki, Motoyuki ,  Dorsey, M. Kristi

IPC分类号： C07K14/08 ,  A61K39/12 ,  C12N15/86 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/55 ,  A61K2039/552 ,  C12N2710/16321 ,  C12N2720/10034 ,  Y10S424/816

摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype I strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.

公开(公告)号：EP1741720A1

公开(公告)日：2007-01-10

申请号：EP06119421.3

申请日：2002-07-11

申请人： ZEON CORPORATION

发明人： Okuda, Takashi Zeon Corp. Res. & Devel. Center ,  Saito, Shuji Zeon Corp. Res. & Devel. Center ,  Dorsey, Kristi M. ,  Tsuzaki, Yoshinari

IPC分类号： C07K14/30 ,  C07K14/055

CPC分类号： A61K39/02 ,  A61K39/0241 ,  A61K39/04 ,  A61K39/12 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/5256 ,  C07K14/005 ,  C07K14/30 ,  C07K2319/00 ,  C07K2319/02 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/24122 ,  C12N2710/24134 ,  C12N2710/24143

摘要： There is provided a DNA molecule derived from a prokaryotic cell in which at least one of the DNA regions encoding NXB (N is asparagine, X is any amino acid other than proline, and B is serine or threonine) has been modified so that no N-glycosylation occurs during the expression in a eukaryotic cell, and since the DNA molecule has been modified at the N-glycosylation site, it produces a non-N-glycosylated protein, which thereby exhibits a high immunogenicity when, for example, it is allowed to produce, in a eukaryotic cell, an antigen protein derived from a prokaryotic cell.

摘要翻译： 提供衍生自原核细胞的DNA分子，其中编码NXB（N为天冬酰胺，X为除脯氨酸以外的任何氨基酸，B为丝氨酸或苏氨酸）的DNA区域中的至少一个已被修饰，使得不存在N 在真核细胞中表达期间发生糖基化，并且由于DNA分子已经在N-糖基化位点被修饰，所以它产生非N-糖基化的蛋白质，从而当例如允许的时候表现出高的免疫原性 在真核细胞中产生源自原核细胞的抗原蛋白。

公开(公告)号：EP1298139A3

公开(公告)日：2003-09-17

申请号：EP02021736.0

申请日：2002-09-25

申请人： Zeon Corporation

发明人： Sato, Takanori ,  Tsuzaki, Yoshinari ,  Esaki, Motoyuki ,  Dorsey, M. Kristi

IPC分类号： C07K14/08 ,  A61K39/12 ,  C12N15/86 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/55 ,  A61K2039/552 ,  C12N2710/16321 ,  C12N2720/10034 ,  Y10S424/816

摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype I strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.