公开(公告)号：EP2768964B1

公开(公告)日：2018-10-10

申请号：EP12775246.7

申请日：2012-10-19

申请人： Intervet International B.V.

发明人： COOK, Stephanie ,  MORSEY, Mohamad ,  PETERSEN, Gary ,  SONDERMEIJER, Paulus Jacobus Antonius

IPC分类号： A61K39/295 ,  A61K39/17 ,  A61K39/255 ,  A61K39/265 ,  C12N15/869 ,  C12N7/01 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10011 ,  C12N2720/10034 ,  C12N2760/18011 ,  C12N2760/18034 ,  C12N2760/18111 ,  C12N2760/18134

摘要： Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of their use in poultry vaccines.

公开(公告)号：EP1471937A1

公开(公告)日：2004-11-03

申请号：EP03704569.7

申请日：2003-02-05

申请人： Lohmann Animal Health GmbH & Co. KG

发明人： OSTERRIEDER, Nikolaus ,  SCHUMACHER, Daniel

IPC分类号： A61K39/255 ,  C12N7/00 ,  C12N5/16 ,  C07K14/055 ,  C12N7/02 ,  C12N15/85 ,  C12N15/00

CPC分类号： C12N15/85 ,  A61K39/12 ,  A61K39/255 ,  C07K14/005 ,  C12N7/00 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2710/16321 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16351 ,  C12N2810/60

摘要： The invention provides a method for producing a continuous cell line capable of supporting the growth of a Marek's disease virus strain comprising infecting or transfecting a cell with a vector comprising a nucleic acid or fragment thereof of a Marek's disease virus strain and culturing said infected or transfected cell or progeny thereof under conditions suitable for the expression of said nucleic acid and propagation of said cell or progeny thereof. Preferably said nucleic acid or fragment thereof comprises a Marek's disease virus glycoprotein gE gene or functional fragment thereof. The invention further provides a method to generate and/or isolate and/or maintain a hypervirulent and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain comprising infecting a cell according to the invention with a hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain and culturing said cell under conditions suitable for the propagation of said cell and the generation, maintenance and isolation of said hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain. The invention further provides a method to prepare a vaccine capable of inducing protection against disease, preferably a Marek's disease virus associated disease in an avian comprising culturing a continuous cell according to the invention and harvesting cell culture components therefrom.

公开(公告)号：EP2831246B1

公开(公告)日：2017-05-03

申请号：EP13713195

申请日：2013-03-29

申请人： CEVA SANTÉ ANIMALE

发明人： FUJISAWA AYUMI ,  KUBOMURA MAYUMI ,  SAEKI SAKIKO ,  SAITO SHUJI

IPC分类号： C12N15/869 ,  A61K39/12 ,  A61K39/17

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10034 ,  C12N2760/18134

摘要： The present invention relates to a recombinant avian herpes virus, which comprises at least two recombinant nucleotide sequences, each recombinant nucleotide sequence encoding a distinct antigenic peptide, wherein said at least two recombinant nucleotide sequences are inserted into distinct non-coding region of the viral genome chosen among the region located between UL44 and UL45, the region located between UL45 and UL46, the region located between US10 and SORF3, the region located between SORF3 and US2.

摘要翻译： 本发明涉及重组禽疱疹病毒，其包含至少两个重组核苷酸序列，每个重组核苷酸序列编码独特的抗原肽，其中所述至少两个重组核苷酸序列被插入病毒基因组的不同非编码区 选自位于UL44和UL45之间的区域，位于UL45和UL46之间的区域，位于US10和SORF3之间的区域，位于SORF3和US2之间的区域。

公开(公告)号：EP2845904A1

公开(公告)日：2015-03-11

申请号：EP13183393.1

申请日：2013-09-06

申请人： Ceva Sante Animale

发明人： Esaki, Motoyuki ,  Saitoh, Shuji ,  Sato, Takanori

IPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/02 ,  A61K39/145 ,  C12N5/10

CPC分类号： A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2710/16371 ,  C12N2720/10034 ,  C12N2720/10051 ,  C12N2720/10071 ,  C12N2760/16034 ,  C12N2760/18134

摘要： The present invention relates recombinant viruses and the uses thereof. More particularly, the invention relates to novel recombinant Marek's disease viruses encoding polypeptide(s) of interest, and their use to express or deliver such polypeptides to animals, particularly poultry. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组病毒及其用途。 更具体地，本发明涉及编码感兴趣多肽的新型重组马立克氏病病毒，以及它们用于将动物特别是家禽表达或递送这些多肽的用途。 本发明特别适用于针对禽类病原体接种家禽。

公开(公告)号：EP3050572A1

公开(公告)日：2016-08-03

申请号：EP15305102.4

申请日：2015-01-29

申请人： Ceva Sante Animale

发明人： Ishihara, Yukari ,  Esaki, Motoyuki ,  Saitoh, Shuji

IPC分类号： A61K39/255

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/5256 ,  A61K2039/552 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16343 ,  C12N2710/16351 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134

摘要： The present invention relates to recombinant MDV1 viruses and the uses thereof. The invention is particularly suited to vaccinate poultry against avian pathogens.

摘要翻译： 本发明涉及重组MDV1病毒及其用途。 本发明特别适用于针对禽类病原体接种家禽。

公开(公告)号：EP1298139B1

公开(公告)日：2007-05-02

申请号：EP02021736.0

申请日：2002-09-25

申请人： ZEON CORPORATION

发明人： Sato, Takanori ,  Tsuzaki, Yoshinari ,  Esaki, Motoyuki ,  Dorsey, M. Kristi

IPC分类号： C07K14/08 ,  A61K39/12 ,  C12N15/86 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/55 ,  A61K2039/552 ,  C12N2710/16321 ,  C12N2720/10034 ,  Y10S424/816

摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype I strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.

公开(公告)号：EP1298139A3

公开(公告)日：2003-09-17

申请号：EP02021736.0

申请日：2002-09-25

申请人： Zeon Corporation

发明人： Sato, Takanori ,  Tsuzaki, Yoshinari ,  Esaki, Motoyuki ,  Dorsey, M. Kristi

IPC分类号： C07K14/08 ,  A61K39/12 ,  C12N15/86 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/55 ,  A61K2039/552 ,  C12N2710/16321 ,  C12N2720/10034 ,  Y10S424/816

摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype I strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene, of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.

公开(公告)号：EP2768964A1

公开(公告)日：2014-08-27

申请号：EP12775246.7

申请日：2012-10-19

申请人： Intervet International B.V.

发明人： COOK, Stephanie ,  MORSEY, Mohamad ,  PETERSEN, Gary ,  SONDERMEIJER, Paulus Jacobus Antonius

IPC分类号： C12N15/86 ,  C12N7/01 ,  C12N15/869 ,  A61K39/245

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16311 ,  C12N2710/16321 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10011 ,  C12N2720/10034 ,  C12N2760/18011 ,  C12N2760/18034 ,  C12N2760/18111 ,  C12N2760/18134

摘要： Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of their use in poultry vaccines.

摘要翻译： 重组价，非致病性马立克氏病病毒的结构做了编码，并同时表达传染性喉气管炎病毒和新城疫病毒蛋白抗原，及其在禽类疫苗的使用方法。

公开(公告)号：EP1471937B1

公开(公告)日：2009-07-22

申请号：EP03704569.7

申请日：2003-02-05

申请人： Lohmann Animal Health GmbH & Co. KG

发明人： OSTERRIEDER, Nikolaus ,  SCHUMACHER, Daniel

IPC分类号： A61K39/255 ,  C12N7/00 ,  C12N5/16 ,  C07K14/055 ,  C12N7/02 ,  C12N15/85 ,  C12N15/00

CPC分类号： C12N15/85 ,  A61K39/12 ,  A61K39/255 ,  C07K14/005 ,  C12N7/00 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2710/16321 ,  C12N2710/16322 ,  C12N2710/16334 ,  C12N2710/16351 ,  C12N2810/60

摘要： The invention provides a method for producing a continuous cell line capable of supporting the growth of a Marek's disease virus strain comprising infecting or transfecting a cell with a vector comprising a nucleic acid or fragment thereof of a Marek's disease virus strain and culturing said infected or transfected cell or progeny thereof under conditions suitable for the expression of said nucleic acid and propagation of said cell or progeny thereof. Preferably said nucleic acid or fragment thereof comprises a Marek's disease virus glycoprotein gE gene or functional fragment thereof. The invention further provides a method to generate and/or isolate and/or maintain a hypervirulent and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain comprising infecting a cell according to the invention with a hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain and culturing said cell under conditions suitable for the propagation of said cell and the generation, maintenance and isolation of said hypervirulent, and/or very virulent, and/or very virulent plus, and/or virulent and/or avirulent Marek's disease virus strain. The invention further provides a method to prepare a vaccine capable of inducing protection against disease, preferably a Marek's disease virus associated disease in an avian comprising culturing a continuous cell according to the invention and harvesting cell culture components therefrom.

公开(公告)号：EP1711619A2

公开(公告)日：2006-10-18

申请号：EP04806704.5

申请日：2004-12-29

申请人： Virumar Pituach Tarkivin Ltd

发明人： SAAR, Yair

IPC分类号： C12Q1/68

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/255 ,  A61K2039/525 ,  A61K2039/552 ,  A61K2039/6006 ,  C12N2710/16321 ,  C12N2710/16334

摘要： Integrated viral complexes, methods of producing them, and their use as a vaccine against is described. Integrated viral complexes are optionally dried and may be stored at refrigeration tememperatures. Integrated viral complexes include viable virions in intact cell membranes. The host cells are non-viable. The invention is advantageously employed in the context of Herpes virus including Marek's disease virus.